Highlights in Aspergillus biology



The selected topics on the bulleted list below link to sets of references compiled by AspGD curators. These lists are intended to provide a brief overview of literature pertaining to each topic, rather than comprehensive bibliographies.


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Selected Topics in Aspergillus nidulans Biology



Carbon Catabolite Repression

Cubero B, Scazzocchio C. Two different, adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. EMBO J. 1994 Jan 15;13(2):407-15.
   

Dowzer CE, Kelly JM. Cloning of the creA gene from Aspergillus nidulans: a gene involved in carbon catabolite repression. Curr Genet. 1989 Jun;15(6):457-9.
   

Dowzer CE, Kelly JM. Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Mol Cell Biol. 1991 Nov;11(11):5701-9.
   

Hynes MJ, Kelly JM. Pleiotropic mutants of Aspergillus nidulans altered in carbon metabolism. Mol Gen Genet. 1977 Jan 18;150(2):193-204.
   

Kelly JM. Carbon catabolite repression. Prog Ind Microbiol. 1994;29:355-67.
   

Kulmburg P, Mathieu M, Dowzer C, Kelly J, Felenbok B. Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol Microbiol. 1993 Mar;7(6):847-57.
   

Mathieu M, Felenbok B. The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator. EMBO J. 1994 Sep 1;13(17):4022-7.
   

Mogensen J, Nielsen HB, Hofmann G, Nielsen J. Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol. Fungal Genet Biol. 2006 Aug;43(8):593-603. Epub 2006 May 15.
   

Panozzo C, Cornillot E, Felenbok B. The CreA repressor is the sole DNA-binding protein responsible for carbon catabolite repression of the alcA gene in Aspergillus nidulans via its binding to a couple of specific sites. J Biol Chem. 1998 Mar 13;273(11):6367-72.
   

Roy P, Lockington RA, Kelly JM. CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA. Fungal Genet Biol. 2008 May;45(5):657-70. Epub 2007 Nov 1.
   

Ruijter GJ, Visser J. Carbon repression in Aspergilli. FEMS Microbiol Lett. 1997 Jun 15;151(2):103-14. Review.
   

Strauss J, Horvath HK, Abdallah BM, Kindermann J, Mach RL, Kubicek CP. The function of CreA, the carbon catabolite repressor of Aspergillus nidulans, is regulated at the transcriptional and post-transcriptional level. Mol Microbiol. 1999 Apr;32(1):169-78.
   

List last updated: July 2010 Back to top



Cell Cycle

Bachewich C, Masker K, Osmani S. The polo-like kinase PLKA is required for initiation and progression through mitosis in the filamentous fungus Aspergillus nidulans. Mol Microbiol. 2005 Jan;55(2):572-87.
   

Bergen LG, Morris NR. Kinetics of the nuclear division cycle of Aspergillus nidulans. J Bacteriol. 1983 Oct;156(1):155-60.
   

Bergen LG, Upshall A, Morris NR. S-phase, G2, and nuclear division mutants of Aspergillus nidulans. J Bacteriol. 1984 Jul;159(1):114-9.
   

De Souza CP, Osmani AH, Hashmi SB, Osmani SA. Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans. Curr Biol. 2004 Nov 23;14(22):1973-84.
   

Enke C, Zekert N, Veith D, Schaaf C, Konzack S, Fischer R. Aspergillus nidulans Dis1/XMAP215 protein AlpA localizes to spindle pole bodies and microtubule plus ends and contributes to growth directionality. Eukaryot Cell. 2007 Mar;6(3):555-62. Epub 2007 Jan 19.
   

Harris SD. The duplication cycle in Aspergillus nidulans. Fungal Genet Biol. 1997 Aug;22(1):1-12. Review.
   

Morris NR, Enos AP. Mitotic gold in a mold: Aspergillus genetics and the biology of mitosis. Trends Genet. 1992 Jan;8(1):32-7. Review.
   

Morris NR, Kirsch DR, Oakley BR. Molecular and genetic methods for studying mitosis and spindle proteins in Aspergillus nidulans. Methods Cell Biol. 1982;25 Pt B:107-30.
   

Nanthakumar NN, Dayton JS, Means AR. Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation. Prog Cell Cycle Res. 1996;2:217-28. Review.
   

Oakley BR. Tubulins in Aspergillus nidulans. Fungal Genet Biol. 2004 Apr;41(4):420-7. Review.
   

Oakley BR, Morris NR. A mutation in Aspergillus nidulans that blocks the transition from interphase to prophase. J Cell Biol. 1983 Apr;96(4):1155-8.
   

O'regan L, Blot J, Fry AM. Mitotic regulation by NIMA-related kinases. Cell Div. 2007 Aug 29;2:25.
   

Osmani AH, Davies J, Liu HL, Nile A, Osmani SA. Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans. Mol Biol Cell. 2006 Dec;17(12):4946-61. Epub 2006 Sep 20.
   

Osmani SA, Mirabito PM. The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans. Fungal Genet Biol. 2004 Apr;41(4):401-10. Review.
   

Osmani SA, Ye XS. Cell cycle regulation in Aspergillus by two protein kinases. Biochem J. 1996 Aug 1;317 ( Pt 3):633-41. Review.
   

Pantazopoulou A, Penalva MA. Organization and dynamics of the Aspergillus nidulans Golgi during apical extension and mitosis. Mol Biol Cell. 2009 Oct;20(20):4335-47. Epub 2009 Aug 19.
   

Wang J, Hu H, Wang S, Shi J, Chen S, Wei H, Xu X, Lu L. The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans. Microbiology. 2009 Aug;155(Pt 8):2714-25. Epub 2009 May 14.
   

Westfall PJ, Momany M. Aspergillus nidulans septin AspB plays pre- and postmitotic roles in septum, branch, and conidiophore development. Mol Biol Cell. 2002 Jan;13(1):110-8.
   

List last updated: July 2010 Back to top



Cell Polarity, Hyphal Growth and Morphology

Harris SD, Turner G, Meyer V, Espeso EA, Specht T, Takeshita N, Helmstedt K. Morphology and development in Aspergillus nidulans: a complex puzzle. Fungal Genet Biol. 2009 Mar;46 Suppl 1:S82-S92.
   

Higashitsuji Y, Herrero S, Takeshita N, Fischer R. The cell end marker protein TeaC is involved in growth directionality and septation in Aspergillus nidulans. Eukaryot Cell. 2009 Jul;8(7):957-67. Epub 2009 May 8.
   

Horio T. Role of microtubules in tip growth of fungi. J Plant Res. 2007 Jan;120(1):53-60. Epub 2006 Oct 5.
   

Horio T, Oakley BR. The role of microtubules in rapid hyphal tip growth of Aspergillus nidulans. Mol Biol Cell. 2005 Feb;16(2):918-26. Epub 2004 Nov 17.
   

Leeder AC, Turner G. Characterisation of Aspergillus nidulans polarisome component BemA. Fungal Genet Biol. 2008 Jun;45(6):897-911. Epub 2007 Dec 8.
   

Momany M. Polarity in filamentous fungi: establishment, maintenance and new axes. Curr Opin Microbiol. 2002 Dec;5(6):580-5. Review.
   

Takeshita N, Higashitsuji Y, Konzack S, Fischer R. Apical sterol-rich membranes are essential for localizing cell end markers that determine growth directionality in the filamentous fungus Aspergillus nidulans. Mol Biol Cell. 2008 Jan;19(1):339-51. Epub 2007 Nov 14.
   

Upadhyay S, Shaw BD. A phosphoglucose isomerase mutant in Aspergillus nidulans is defective in hyphal polarity and conidiation. Fungal Genet Biol. 2006 Nov;43(11):739-51. Epub 2006 Jun 22.
   

Shaw BD, Upadhyay S. Aspergillus nidulans swoK encodes an RNA binding protein that is important for cell polarity. Fungal Genet Biol. 2005 Oct;42(10):862-72.
   

Yang Y, El-Ganiny AM, Bray GE, Sanders DA, Kaminskyj SG. Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis. Fungal Genet Biol. 2008 May;45(5):749-59. Epub 2007 Dec 10.
   

List last updated: July 2010 Back to top



Cell Wall of Conidia and Hyphae

Bouzarelou D, Billini M, Roumelioti K, Sophianopoulou V. EglD, a putative endoglucanase, with an expansin like domain is localized in the conidial cell wall of Aspergillus nidulans. Fungal Genet Biol. 2008 Jun;45(6):839-50. Epub 2008 Mar 10.
   

Chiu YH, Xiang X, Dawe AL, Morris NR. Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal. Mol Biol Cell. 1997 Sep;8(9):1735-49.
   

de Groot PW, Brandt BW, Horiuchi H, Ram AF, de Koster CG, Klis FM. Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans. Fungal Genet Biol. 2009 Mar;46 Suppl 1:S72-81.
   

Dynesen J, Nielsen J. Surface hydrophobicity of Aspergillus nidulans conidiospores and its role in pellet formation. Biotechnol Prog. 2003 May-Jun;19(3):1049-52.
   

Ma H, Snook LA, Kaminskyj SG, Dahms TE. Surface ultrastructure and elasticity in growing tips and mature regions of Aspergillus hyphae describe wall maturation. Microbiology. 2005 Nov;151(Pt 11):3679-88.
   

Ma H, Snook LA, Tian C, Kaminskyj SG, Dahms TE. Fungal surface remodelling visualized by atomic force microscopy. Mycol Res. 2006 Aug;110(Pt 8):879-86. Epub 2006 Aug 7.
   

Sewall TC, Mims CW, Timberlake WE. Conidium differentiation in Aspergillus nidulans wild-type and wet-white (wetA) mutant strains. Dev Biol. 1990 Apr;138(2):499-508.
   

Stringer MA, Timberlake WE. dewA encodes a fungal hydrophobin component of the Aspergillus spore wall. Mol Microbiol. 1995 Apr;16(1):33-44.
   

List last updated: July 2010 Back to top



Conidial Germination

Belaish R, Sharon H, Levdansky E, Greenstein S, Shadkchan Y, Osherov N. The Aspergillus nidulans cetA and calA genes are involved in conidial germination and cell wall morphogenesis. Fungal Genet Biol. 2008 Mar;45(3):232-42. Epub 2007 Jul 20.
   

Breakspear A, Momany M. Aspergillus nidulans conidiation genes dewA, fluG, and stuA are differentially regulated in early vegetative growth. Eukaryot Cell. 2007 Sep;6(9):1697-700. Epub 2007 Jul 13.
   

Chang MH, Chae KS, Han DM, Jahng KY. The GanB Galpha-protein negatively regulates asexual sporulation and plays a positive role in conidial germination in Aspergillus nidulans. Genetics. 2004 Jul;167(3):1305-15.
   

Donnelly E, Barnett YA, McCullough W. Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage. FEBS Lett. 1994 Nov 28;355(2):201-4.
   

Fillinger S, Chaveroche MK, Shimizu K, Keller N, d'Enfert C. cAMP and ras signalling independently control spore germination in the filamentous fungus Aspergillus nidulans. Mol Microbiol. 2002 May;44(4):1001-16.
   

Lafon A, Seo JA, Han KH, Yu JH, d'Enfert C. The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans. Genetics. 2005 Sep;171(1):71-80. Epub 2005 Jun 8.
   

Momany M. Polarity in filamentous fungi: establishment, maintenance and new axes. Curr Opin Microbiol. 2002 Dec;5(6):580-5. Review.
   

Osherov N, May G. Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis. Genetics. 2000 Jun;155(2):647-56.
   

Upadhyay S, Shaw BD. A phosphoglucose isomerase mutant in Aspergillus nidulans is defective in hyphal polarity and conidiation. Fungal Genet Biol. 2006 Nov;43(11):739-51. Epub 2006 Jun 22.
   

Winther MD, Stevens L. RNA synthesis during the germination of conidia of Aspergillus nidulans. Microbios. 1981;30(121-122):153-62.
   

List last updated: July 2010 Back to top



Conidiation and Asexual Development

Adams TH, Boylan MT, Timberlake WE. brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell. 1988 Jul 29;54(3):353-62.
   

Adams TH, Wieser JK, Yu JH. Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev. 1998 Mar;62(1):35-54. Review. Erratum in: Microbiol Mol Biol Rev 1998 Jun;62(2):545.
   

Boylan MT, Mirabito PM, Willett CE, Zimmerman CR, Timberlake WE. Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans. Mol Cell Biol. 1987 Sep;7(9):3113-8.
   

Calvo AM. The VeA regulatory system and its role in morphological and chemical development in fungi. Fungal Genet Biol. 2008 Jul;45(7):1053-61. Epub 2008 Mar 31. Review.
   

Calvo AM, Wilson RA, Bok JW, Keller NP. Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev. 2002 Sep;66(3):447-59, table of contents. Review.
   

Chang MH, Chae KS, Han DM, Jahng KY. The GanB Galpha-protein negatively regulates asexual sporulation and plays a positive role in conidial germination in Aspergillus nidulans. Genetics. 2004 Jul;167(3):1305-15.
   

Chang YC, Timberlake WE. Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast. Genetics. 1993 Jan;133(1):29-38.
   

Dutton JR, Johns S, Miller BL. StuAp is a sequence-specific transcription factor that regulates developmental complexity in Aspergillus nidulans. EMBO J. 1997 Sep 15;16(18):5710-21.
   

Han S, Adams TH. Complex control of the developmental regulatory locus brlA in Aspergillus nidulans. Mol Genet Genomics. 2001 Oct;266(2):260-70.
   

Lee BN, Adams TH. FluG and flbA function interdependently to initiate conidiophore development in Aspergillus nidulans through brlA beta activation. EMBO J. 1996 Jan 15;15(2):299-309.
   

Marhoul J, Adams TH. Isolation of Aspergillus nidulans Mutants That Overcome brlA-Induced Growth Arrest Fungal Genet Biol. 1997 Feb;21(1):109-17.
   

Marshall MA, Timberlake WE. Aspergillus nidulans wetA activates spore-specific gene expression. Mol Cell Biol. 1991 Jan;11(1):55-62.
   

Mooney JL, Yager LN. Light is required for conidiation in Aspergillus nidulans. Genes Dev. 1990 Sep;4(9):1473-82.
   

Ni M, Yu JH. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS One. 2007 Oct 3;2(10):e970.
   

Oliver PT. Conidiophore and spore development in Aspergillus nidulans. J Gen Microbiol. 1972 Nov;73(1):45-54.
   

Prade RA, Timberlake WE. The Aspergillus nidulans brlA regulatory locus consists of overlapping transcription units that are individually required for conidiophore development. EMBO J. 1993 Jun;12(6):2439-47.
   

Seo JA, Guan Y, Yu JH. Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans. Genetics. 2003 Nov;165(3):1083-93.
   

Seo JA, Guan Y, Yu JH. FluG-dependent asexual development in Aspergillus nidulans occurs via derepression. Genetics. 2006 Mar;172(3):1535-44. Epub 2005 Dec 30.
   

Sewall TC, Mims CW, Timberlake WE. abaA controls phialide differentiation in Aspergillus nidulans. Plant Cell. 1990 Aug;2(8):731-9.
   

Timberlake WE. Temporal and spatial controls of Aspergillus development. Curr Opin Genet Dev. 1991 Oct;1(3):351-7. Review.
   

Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans. Eukaryot Cell. 2004 Dec;3(6):1398-411.
   

Weatherbee JA, May GS, Gambino J, Morris NR. Involvement of a particular species of beta-tubulin (beta 3) in conidial development in Aspergillus nidulans. J Cell Biol. 1985 Sep;101(3):706-11.
   

Wieser J, Yu JH, Adams TH. Dominant mutations affecting both sporulation and sterigmatocystin biosynthesis in Aspergillus nidulans. Curr Genet. 1997 Sep;32(3):218-24.
   

Ye XS, Lee SL, Wolkow TD, McGuire SL, Hamer JE, Wood GC, Osmani SA. Interaction between developmental and cell cycle regulators is required for morphogenesis in Aspergillus nidulans. EMBO J. 1999 Dec 15;18(24):6994-7001.
   

List last updated: July 2010 Back to top



DNA Damage Response

De Souza CP, Hashmi SB, Horn KP, Osmani SA. A point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivity. Genetics. 2006 Dec;174(4):1881-93. Epub 2006 Oct 8.
   

Goldman GH, Kafer E. Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes. Fungal Genet Biol. 2004 Apr;41(4):428-42. Review.
   

Goldman GH, McGuire SL, Harris SD. The DNA damage response in filamentous fungi. Fungal Genet Biol. 2002 Apr;35(3):183-95. Review.
   

Harris SD, Kraus PR. Regulation of septum formation in Aspergillus nidulans by a DNA damage checkpoint pathway. Genetics. 1998 Mar;148(3):1055-67.
   

Malavazi I, Lima JF, de Castro PA, Savoldi M, de Souza Goldman MH, Goldman GH. Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway. Genetics. 2008 Feb;178(2):675-91. Epub 2008 Feb 1.
   

Malavazi I, Savoldi M, Di Mauro SM, Menck CF, Harris SD, Goldman MH, Goldman GH. Transcriptome analysis of Aspergillus nidulans exposed to camptothecin-induced DNA damage. Eukaryot Cell. 2006 Oct;5(10):1688-704.
   

Malavazi I, Semighini CP, Kress MR, Harris SD, Goldman GH. Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA. Genetics. 2006 May;173(1):99-109. Epub 2006 Jan 16.
   

List last updated: July 2010 Back to top



Laboratory Methods and Molecular Tools

Bennett JW. Aspergillus: a primer for the novice. Med Mycol. 2009;47 Suppl 1:S5-12. Epub 2009 Feb 27. Review.
   

Hickey PC, Read ND. Imaging living cells of Aspergillus in vitro. Med Mycol. 2009;47 Suppl 1:S110-9. Epub 2009 Mar 2.
   

Morris NR. Preparation of large molecular weight DNA from the fungus Aspergillus nidulans. J Gen Microbiol. 1978 Jun;106(2):387-9.
   

Morris NR, Kirsch DR, Oakley BR. Molecular and genetic methods for studying mitosis and spindle proteins in Aspergillus nidulans. Methods Cell Biol. 1982;25 Pt B:107-30.
   

Oakley BR. Methods for isolating and analyzing mitotic mutants in Aspergillus nidulans. Methods Cell Biol. 1999;61:347-68. Review.
   

Todd RB, Davis MA, Hynes MJ. Genetic manipulation of Aspergillus nidulans: meiotic progeny for genetic analysis and strain construction. Nat Protoc. 2007;2(4):811-21.
   

Yang L, Ukil L, Osmani A, Nahm F, Davies J, De Souza CP, Dou X, Perez-Balaguer A, Osmani SA. Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in Aspergillus nidulans. Eukaryot Cell. 2004 Oct;3(5):1359-62.
   

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Mating and Sexual Development

Bayram O, Biesemann C, Krappmann S, Galland P, Braus GH. More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development. Mol Biol Cell. 2008 Aug;19(8):3254-62. Epub 2008 May 21.
   

Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science. 2008 Jun 13;320(5882):1504-6.
   

Bruggeman J, Debets AJ, Swart K, Hoekstra RF. Male and female roles in crosses of Aspergillus nidulans as revealed by vegetatively incompatible parents. Fungal Genet Biol. 2003 Jul;39(2):136-41.
   

Eisendle M, Schrettl M, Kragl C, Muller D, Illmer P, Haas H. The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell. 2006 Oct;5(10):1596-603.
   

Kim HR, Chae KS, Han KH, Han DM. The nsdC gene encoding a putative C2H2-type transcription factor is a key activator of sexual development in Aspergillus nidulans. Genetics. 2009 Jul;182(3):771-83. Epub 2009 May 4.
   

Paoletti M, Seymour FA, Alcocer MJ, Kaur N, Calvo AM, Archer DB, Dyer PS. Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans. Curr Biol. 2007 Aug 21;17(16):1384-9. Epub 2007 Aug 2.
   

Seo JA, Han KH, Yu JH. The gprA and gprB genes encode putative G protein-coupled receptors required for self-fertilization in Aspergillus nidulans. Mol Microbiol. 2004 Sep;53(6):1611-23.
   

Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans. Eukaryot Cell. 2004 Dec;3(6):1398-411.
   

Vienken K, Fischer R. The Zn(II)2Cys6 putative transcription factor NosA controls fruiting body formation in Aspergillus nidulans. Mol Microbiol. 2006 Jul;61(2):544-54. Epub 2006 Jun 15.
   

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Nitrogen Catabolite Repression

Andrianopoulos A, Kourambas S, Sharp JA, Davis MA, Hynes MJ. Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression. J Bacteriol. 1998 Apr;180(7):1973-7.
   

Caddick MX, Jones MG, van Tonder JM, Le Cordier H, Narendja F, Strauss J, Morozov IY. Opposing signals differentially regulate transcript stability in Aspergillus nidulans. Mol Microbiol. 2006 Oct;62(2):509-19.
   

Caddick MX, Peters D, Platt A. Nitrogen regulation in fungi. Antonie Van Leeuwenhoek. 1994;65(3):169-77. Review.
   

Davis MA, Kelly JM, Hynes MJ. Fungal catabolic gene regulation: molecular genetic analysis of the amdS gene of Aspergillus nidulans. Genetica. 1993;90(2-3):133-45. Review.
   

Fraser JA, Davis MA, Hynes MJ. The formamidase gene of Aspergillus nidulans: regulation by nitrogen metabolite repression and transcriptional interference by an overlapping upstream gene. Genetics. 2001 Jan;157(1):119-31.
   

Margelis S, D'Souza C, Small AJ, Hynes MJ, Adams TH, Davis MA. Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans. J Bacteriol. 2001 Oct;183(20):5826-33.
   

Morozov IY, Galbis-Martinez M, Jones MG, Caddick MX. Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA. Mol Microbiol. 2001 Oct;42(1):269-77.
   

Wilson RA, Arst HN Jr. Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors. Microbiol Mol Biol Rev. 1998 Sep;62(3):586-96. Review.
   

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Nuclear Migration and Distribution

Clutterbuck AJ. Mutants of Aspergillus nidulans deficient in nuclear migration during hyphal growth and conidiation. Microbiology. 1994 May;140 ( Pt 5):1169-74.
   

Fischer R. Nuclear movement in filamentous fungi. FEMS Microbiol Rev. 1999 Jan;23(1):39-68. Review.
   

Oakley BR, Morris NR. Nuclear movement is beta--tubulin-dependent in Aspergillus nidulans. Cell. 1980 Jan;19(1):255-62.
   

Suelmann R, Fischer R. Nuclear migration in fungi--different motors at work. Res Microbiol. 2000 May;151(4):247-54. Review.
   

Suelmann R, Sievers N, Fischer R. Nuclear traffic in fungal hyphae: in vivo study of nuclear migration and positioning in Aspergillus nidulans. Mol Microbiol. 1997 Aug;25(4):757-69.
   

Xiang X, Beckwith SM, Morris NR. Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2100-4.
   

Xiang X, Fischer R. Nuclear migration and positioning in filamentous fungi. Fungal Genet Biol. 2004 Apr;41(4):411-9. Review.
   

Xiang X, Osmani AH, Osmani SA, Roghi CH, Willins DA, Beckwith S, Goldman G, Chiu Y, Xin M, Liu B, et al. Analysis of nuclear migration in Aspergillus nidulans. Cold Spring Harb Symp Quant Biol. 1995;60:813-9.
   

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Pathogenesis of Aspergillus nidulans

Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN Jr, Rogers T. The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol. 2005 Feb;55(4):1072-84.
   

Dellepiane RM, Tortorano AM, Liotto N, Laicini E, Di Landro G, Carnelli V, Pietrogrande MC. Invasive Aspergillus nidulans infection in a patient with chronic granulomatous disease. Mycoses. 2008 Sep;51(5):458-60. Epub 2008 Jan 30.
   

Drake CH. The pathogenicity of Aspergillus nidulans. Mycopathologia. 1948 Jan;4(2):103-19.
   

Hua X, Yuan X, Wilhelmus KR. A fungal pH-responsive signaling pathway regulating Aspergillus adaptation and invasion into the cornea. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1517-23. Epub 2009 Oct 22.
   

Purnell DM. The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice. Mycopathol Mycol Appl. 1973 Jul 31;50(3):195-203.
   

Purnell DM. The histopathologic response of mice to Aspergillus nidulans: comparison between genetically defined haploid and diploid strains of different virulence. Drugs. 1974;7(1):95-104.
   

Purnell DM. Quantitative tissue invasion of the murine brain as a phenotypic marker of strain virulence in Aspergillus nidulans. Sabouraudia. 1975 Jul;13(2):209-16.
   

Russo G, Graziosi F. [Pathogenic power of Aspergillus nidulans under experimental conditions.] Rend Ist Sup Sanit. 1950;13(1):46-56.
   

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Secondary Metabolism

Adams TH, Yu JH. Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans. Curr Opin Microbiol. 1998 Dec;1(6):674-7. Review.
   

Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science. 2008 Jun 13;320(5882):1504-6.
   

Bergmann S, Schumann J, Scherlach K, Lange C, Brakhage AA, Hertweck C. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol. 2007 Apr;3(4):213-7. Epub 2007 Mar 18.
   

Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP. Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol. 2009 Jul;5(7):462-4.
   

Brakhage AA, Schroeckh V. Fungal secondary metabolites - Strategies to activate silent gene clusters. Fungal Genet Biol. 2010 Apr 28. [Epub ahead of print]
   

Calvo AM, Wilson RA, Bok JW, Keller NP. Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev. 2002 Sep;66(3):447-59, table of contents. Review.
   

Schroeckh V, Scherlach K, Nutzmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14558-63. Epub 2009 Aug 6.
   

Seo JA, Guan Y, Yu JH. Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans. Genetics. 2003 Nov;165(3):1083-93.
   

Sprote P, Hynes MJ, Hortschansky P, Shelest E, Scharf DH, Wolke SM, Brakhage AA. Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol. 2008 Oct;70(2):445-61.
   

Szewczyk E, Chiang YM, Oakley CE, Davidson AD, Wang CC, Oakley BR. Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. Appl Environ Microbiol. 2008 Dec;74(24):7607-12. Epub 2008 Oct 31.
   

Wieser J, Yu JH, Adams TH. Dominant mutations affecting both sporulation and sterigmatocystin biosynthesis in Aspergillus nidulans. Curr Genet. 1997 Sep;32(3):218-24.
   

List last updated: July 2010 Back to top



Selected Topics in Aspergillus fumigatus Biology



Reviews about Aspergillus fumigatus

Bennett JW. Aspergillus: a primer for the novice. Med Mycol. 2009;47 Suppl 1:S5-12. Epub 2009 Feb 27.
   

Brakhage AA, Langfelder K. Menacing mold: the molecular biology of Aspergillus fumigatus. Annu Rev Microbiol. 2002;56:433-55. Epub 2002 Jan 30.
   

Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev. 1999 Apr;12(2):310-50.
   

Tekaia F, Latge JP. Aspergillus fumigatus: saprophyte or pathogen? Curr Opin Microbiol. 2005 Aug;8(4):385-92.
  v 

McCormick A, Loeffler J, Ebel F. Aspergillus fumigatus: contours of an opportunistic human pathogen. Cell Microbiol. 2010 Nov;12(11):1535-43. doi: 10.1111/j.1462-5822.2010.01517.x. Epub 2010 Sep 16.
   

List last updated: July 2011 Back to top



Allergens

Banerjee B, Greenberger PA, Fink JN, Kurup VP. Molecular characterization of aspergillus fumigatus allergens. Indian J Chest Dis Allied Sci. 2000 Oct-Dec;42(4):239-48.
   

Fraczek MG, Rashid R, Denson M, Denning DW, Bowyer P. Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP. Clin Mol Allergy. 2010 Nov 3;8:15.
   

Kurup VP. Aspergillus antigens: which are important? Med Mycol. 2005 May;43 Suppl 1:S189-96.
   

Singh B, Oellerich M, Kumar R, Kumar M, Bhadoria DP, Reichard U, Gupta VK, Sharma GL, Asif AR. Immuno-reactive molecules identified from the secreted proteome of Aspergillus fumigatus. J Proteome Res. 2010 Nov 5;9(11):5517-29. Epub 2010 Sep 30.
   

Singh B, Sharma GL, Oellerich M, Kumar R, Singh S, Bhadoria DP, Katyal A, Reichard U, Asif AR. Novel cytosolic allergens of Aspergillus fumigatus identified from germinating conidia. J Proteome Res. 2010 Nov 5;9(11):5530-41. Epub 2010 Oct 7.
   

Vijay HM, Kurup VP. Fungal allergens. Clin Allergy Immunol. 2008;21:141-60.
   

List last updated: 07/15/2011 Back to top



Asexual Development

Fortwendel JR, Fuller KK, Stephens TJ, Bacon WC, Askew DS, Rhodes JC. Aspergillus fumigatus RasA regulates asexual development and cell wall integrity. Eukaryot Cell. 2008 Sep;7(9):1530-9. Epub 2008 Jul 7.
   

Fortwendel JR, Panepinto JC, Seitz AE, Askew DS, Rhodes JC. Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development. Fungal Genet Biol. 2004 Feb;41(2):129-39.
   

Mah JH, Yu JH. Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Eukaryot Cell. 2006 Oct;5(10):1585-95.
   

Shin KS, Kwon NJ, Yu JH. Gbetagamma-mediated growth and developmental control in Aspergillus fumigatus. Curr Genet. 2009 Dec;55(6):631-41. Epub 2009 Nov 14.
   

Tao L, Yu JH. AbaA and WetA govern distinct stages of Aspergillus fumigatus development. Microbiology. 2011 Feb;157(Pt 2):313-26. Epub 2010 Oct 21.
   

List last updated: July 2011 Back to top



Biofilms

Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Muuller FM. Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics. 2010 Sep;10(17):3097-107.
   

Mowat E, Butcher J, Lang S, Williams C, Ramage G. Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J Med Microbiol. 2007 Sep;56(Pt 9):1205-12.
   

Mowat E, Lang S, Williams C, McCulloch E, Jones B, Ramage G. Phase-dependent antifungal activity against Aspergillus fumigatus developing multicellular filamentous biofilms. J Antimicrob Chemother. 2008 Dec;62(6):1281-4. Epub 2008 Sep 26.
   

List last updated: July 2011 Back to top



Conidial and Hyphal Cell Wall

Bernard M, Latge JP. Aspergillus fumigatus cell wall: composition and biosynthesis. Med Mycol. 2001;39 Suppl 1:9-17.
   

Chabane S, Sarfati J, Ibrahim-Granet O, Du C, Schmidt C, Mouyna I, Prevost MC, Calderone R, Latge JP. Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus. Appl Environ Microbiol. 2006 May;72(5):3259-67.
   

Dague E, Alsteens D, Latge JP, Dufrene YF. High-resolution cell surface dynamics of germinating Aspergillus fumigatus conidia. Biophys J. 2008 Jan 15;94(2):656-60. Epub 2007 Sep 21.
   

Girardin H, Paris S, Rault J, Bellon-Fontaine MN, Latge JP. The role of the rodlet structure on the physicochemical properties of Aspergillus conidia. Lett Appl Microbiol. 1999 Dec;29(6):364-9.
   

Gastebois A, Clavaud C, Aimanianda V, Latge JP. Aspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organization. Future Microbiol. 2009 Jun;4(5):583-95.
   

Latge JP, Mouyna I, Tekaia F, Beauvais A, Debeaupuis JP, Nierman W. Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus. Med Mycol. 2005 May;43 Suppl 1:S15-22.
   

Levdansky E, Kashi O, Sharon H, Shadkchan Y, Osherov N. The Aspergillus fumigatus cspA gene encoding a repeat-rich cell wall protein is important for normal conidial cell wall architecture and interaction with host cells. Eukaryot Cell. 2010 Sep;9(9):1403-15. Epub 2010 Jul 23.
   

Momany M, Lindsey R, Hill TW, Richardson EA, Momany C, Pedreira M, Guest GM, Fisher JF, Hessler RB, Roberts KA. The Aspergillus fumigatus cell wall is organized in domains that are remodelled during polarity establishment. Microbiology. 2004 Oct;150(Pt 10):3261-8.
   

Paris S, Debeaupuis JP, Crameri R, Carey M, Charles F, Prevost MC, Schmitt C, Philippe B, Latge JP. Conidial hydrophobins of Aspergillus fumigatus. Appl Environ Microbiol. 2003 Mar;69(3):1581-8.
   

Pihet M, Vandeputte P, Tronchin G, Renier G, Saulnier P, Georgeault S, Mallet R, Chabasse D, Symoens F, Bouchara JP. Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia. BMC Microbiol. 2009 Aug 24;9:177.
   

List last updated: July 2011 Back to top



Conidial Germination

Cramer RA Jr, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell. 2008 Jul;7(7):1085-97. Epub 2008 May 2.
   

Romano J, Nimrod G, Ben-Tal N, Shadkchan Y, Baruch K, Sharon H, Osherov N. Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology. 2006 Jul;152(Pt 7):1919-28.
   

Fontaine T, Beauvais A, Loussert C, Thevenard B, Fulgsang CC, Ohno N, Clavaud C, Prevost MC, Latge JP. Cell wall alpha1-3glucans induce the aggregation of germinating conidia of Aspergillus fumigatus. Fungal Genet Biol. 2010 Aug;47(8):707-12. Epub 2010 May 4.
   

List last updated: July 2011 Back to top



Drug Resistance

Arendrup MC, Mavridou E, Mortensen KL, Snelders E, Frimodt-Moller N, Khan H, Melchers WJ, Verweij PE. Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence PLoS One. 2010 Apr 9;5(4):e10080.
   

Cowen LE. Hsp90 orchestrates stress response signaling governing fungal drug resistance. PLoS Pathog. 2009 Aug;5(8):e1000471. Epub 2009 Aug 28.
   

Morschhauser J. Regulation of multidrug resistance in pathogenic fungi. Fungal Genet Biol. 2010 Feb;47(2):94-106. Epub 2009 Aug 7.
   

Shapiro RS, Robbins N, Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev. 2011 Jun;75(2):213-67.
   

List last updated: July 2011 Back to top



Host-Pathogen Interactions

Aimanianda V, Latge JP. Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia. Virulence. 2010 May-Jun;1(3):185-7.
   

Brummer E, Choi JH, Stevens DA. Interaction between conidia, lung macrophages, immunosuppressants, proinflammatory cytokines and transcriptional regulation. Med Mycol. 2005 May;43 Suppl 1:S177-9.
   

Dagenais TR, Giles SS, Aimanianda V, Latge JP, Hull CM, Keller NP. Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infect Immun. 2010 Feb;78(2):823-9. Epub 2009 Nov 16.
   

Denikus N, Orfaniotou F, Wulf G, Lehmann PF, Monod M, Reichard U. Fungal antigens expressed during invasive aspergillosis. Infect Immun. 2005 Aug;73(8):4704-13.
   

Gil ML, Penalver MC, Lopez-Ribot JL, O'Connor JE, Martinez JP. Binding of extracellular matrix proteins to Aspergillus fumigatus conidia. Infect Immun. 1996 Dec;64(12):5239-47.
   

Jahn B, Boukhallouk F, Lotz J, Langfelder K, Wanner G, Brakhage AA. Interaction of human phagocytes with pigmentless Aspergillus conidia. Infect Immun. 2000 Jun;68(6):3736-9.
   

Latge JP, Calderone R. Host-microbe interactions: fungi invasive human fungal opportunistic infections. Curr Opin Microbiol. 2002 Aug;5(4):355-8.
   

McCormick A, Heesemann L, Wagener J, Marcos V, Hartl D, Loeffler J, Heesemann J, Ebel F. NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus. Microbes Infect. 2010 Nov;12(12-13):928-36. Epub 2010 Jul 17.
   

Mircescu MM, Lipuma L, van Rooijen N, Pamer EG, Hohl TM. Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J Infect Dis. 2009 Aug 15;200(4):647-56.
   

Wasylnka JA, Hissen AH, Wan AN, Moore MM. Intracellular and extracellular growth of Aspergillus fumigatus. Med Mycol. 2005 May;43 Suppl 1:S27-30.
   

Zelante T, Bozza S, De Luca A, D'Angelo C, Bonifazi P, Moretti S, Giovannini G, Bistoni F, Romani L. Th17 cells in the setting of Aspergillus infection and pathology. Med Mycol. 2009;47 Suppl 1:S162-9. Epub 2008 Jun 4.
   

List last updated: July 2011 Back to top



Host Response to A. fumigatus

Aimanianda V, Latge JP. Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia. Virulence. 2010 May-Jun;1(3):185-7.
   

Balloy V, Chignard M. The innate immune response to Aspergillus fumigatus. Microbes Infect. 2009 Oct;11(12):919-27. Epub 2009 Jul 15.
   

Bhatia S, Fei M, Yarlagadda M, Qi Z, Akira S, Saijo S, Iwakura Y, van Rooijen N, Gibson GA, St Croix CM, Ray A, Ray P. Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One. 2011 Jan 5;6(1):e15943.
   

Chai LY, Kullberg BJ, Vonk AG, Warris A, Cambi A, Latge JP, Joosten LA, van der Meer JW, Netea MG. Modulation of Toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus. Infect Immun. 2009 May;77(5):2184-92. Epub 2009 Feb 9.
   

Chai LY, Netea MG, Sugui J, Vonk AG, van de Sande WW, Warris A, Kwon-Chung KJ, Jan Kullberg B. Aspergillus fumigatus Conidial Melanin Modulates Host Cytokine Response. Immunobiology. 2009 Nov 23.
   

Chai LY, Vonk AG, Kullberg BJ, Verweij PE, Verschueren I, van der Meer JW, Joosten LA, Latge JP, Netea MG. Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses. Microbes Infect. 2011 Feb;13(2):151-9. Epub 2010 Nov 4.
   

Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol. 2006 Mar 15;176(6):3717-24.
   

Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol. 2007 Feb;9(2):368-81. Epub 2006 Aug 31.
   

McCormick A, Heesemann L, Wagener J, Marcos V, Hartl D, Loeffler J, Heesemann J, Ebel F. NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus. Microbes Infect. 2010 Nov;12(12-13):928-36. Epub 2010 Jul 17.
   

Segal BH. Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist. 2007;12 Suppl 2:7-13.
   

Steele C, Rapaka RR, Metz A, Pop SM, Williams DL, Gordon S, Kolls JK, Brown GD. The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog. 2005 Dec;1(4):e42. Epub 2005 Dec 9.
   

List last updated: July 2011 Back to top



A. fumigatus Response to Host

Cairns T, Minuzzi F, Bignell E. The host-infecting fungal transcriptome. FEMS Microbiol Lett. 2010 Jun;307(1):1-11.
   

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E. Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog. 2008 Sep 12;4(9):e1000154.
   

Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J. The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. PLoS One. 2011 Jan 14;6(1):e16016.
   

Sugui JA, Kim HS, Zarember KA, Chang YC, Gallin JI, Nierman WC, Kwon-Chung KJ. Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils. PLoS One. 2008 Jul 9;3(7):e2655.
   

List last updated: July 2011 Back to top



Mating and Sexual Development

Alvarez-Perez S, Blanco JL, Alba P, Garcia ME. Mating type and invasiveness are significantly associated in Aspergillus fumigatus. Med Mycol. 2010 Mar;48(2):273-7.
   

Cheema MS, Christians JK. Virulence in an insect model differs between mating types in Aspergillus fumigatus. Med Mycol. 2011 Feb;49(2):202-7. Epub 2010 Sep 6.
   

Dyer PS, Paoletti M. Reproduction in Aspergillus fumigatus: sexuality in a supposedly asexual species? Med Mycol. 2005 May;43 Suppl 1:S7-14.
   

Geiser DM. Sexual structures in Aspergillus: morphology, importance and genomics. Med Mycol. 2009;47 Suppl 1:S21-6. Epub 2008 Jun 4.
   

Kronstad JW. Self-fertility: the genetics of sex in lonely fungi. Curr Biol. 2007 Oct 9;17(19):R843-5.
   

Kwon-Chung KJ, Sugui JA. Sexual reproduction in Aspergillus species of medical or economical importance: why so fastidious? Trends Microbiol. 2009 Nov;17(11):481-7. Epub 2009 Sep 23.
   

Mah JH, Yu JH. Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Eukaryot Cell. 2006 Oct;5(10):1585-95.
   

O'Gorman CM, Fuller HT, Dyer PS. Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus. Nature. 2009 Jan 22;457(7228):471-4.
   

Paoletti M, Rydholm C, Schwier EU, Anderson MJ, Szakacs G, Lutzoni F, Debeaupuis JP, Latge JP, Denning DW, Dyer PS. Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol. 2005 Jul 12;15(13):1242-8.
   

Varga J. Mating type gene homologues in Aspergillus fumigatus. Microbiology. 2003 Apr;149(Pt 4):816-9.
   

Kwon-Chung KJ, Sugui JA. Sexual reproduction in Aspergillus species of medical or economical importance: why so fastidious? Trends Microbiol. 2009 Nov;17(11):481-7. Epub 2009 Sep 23.
   

List last updated: July 2011 Back to top



Models of Infection

Ben-Ami R, Lewis RE, Leventakos K, Latge JP, Kontoyiannis DP. Cutaneous model of invasive aspergillosis. Antimicrob Agents Chemother. 2010 May;54(5):1848-54. Epub 2010 Feb 9.
   

Chilvers ER, Spreadbury CL, Cohen J. Bronchoalveolar lavage in an immunosuppressed rabbit model of invasive pulmonary aspergillosis. Mycopathologia. 1989 Dec;108(3):163-71.
   

Lionakis MS, Kontoyiannis DP. The growing promise of Toll-deficient Drosophila melanogaster as a model for studying Aspergillus pathogenesis and treatment. Virulence. 2011 Jan 10;1(6):488-99. Epub 2010 Nov 1.
   

Sarfati J, Diaquin M, Debeaupuis JP, Schmidt A, Lecaque D, Beauvais A, Latge JP. A new experimental murine aspergillosis model to identify strains of Aspergillus fumigatus with reduced virulence. Nippon Ishinkin Gakkai Zasshi. 2002;43(4):203-13.
   

Schmidt A. Animal models of aspergillosis - also useful for vaccination strategies? Mycoses. 2002 Feb;45(1-2):38-40.
   

Sheppard DC, Rieg G, Chiang LY, Filler SG, Edwards JE Jr, Ibrahim AS. Novel inhalational murine model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2004 May;48(5):1908-11.
   

Stephens-Romero SD, Mednick AJ, Feldmesser M. The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy. Infect Immun. 2005 Jan;73(1):114-25.
   

List last updated: July 2011 Back to top



Virulence and Pathogenesis

Askew DS. Aspergillus fumigatus: virulence genes in a street-smart mold. Curr Opin Microbiol. 2008 Aug;11(4):331-7. Epub 2008 Jun 23.
   

Brakhage AA, Liebmann B. Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulence. Med Mycol. 2005 May;43 Suppl 1:S75-82.
   

Cheema MS, Christians JK. Virulence in an insect model differs between mating types in Aspergillus fumigatus. Med Mycol. 2011 Feb;49(2):202-7. Epub 2010 Sep 6.
   

Cramer RA Jr, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell. 2008 Jul;7(7):1085-97. Epub 2008 May 2.
   

Dagenais TR, Keller NP. Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis. Clin Microbiol Rev. 2009 Jul;22(3):447-65.
   

Krappmann S, Braus GH. Nitrogen metabolism of Aspergillus and its role in pathogenicity. Med Mycol. 2005 May;43 Suppl 1:S31-40.
   

Rementeria A, Lopez-Molina N, Ludwig A, Vivanco AB, Bikandi J, Ponton J, Garaizar J. Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol. 2005 Mar;22(1):1-23.
   

Rhodes JC. Aspergillus fumigatus: growth and virulence. Med Mycol. 2006 Sep;44 Suppl 1:S77-81.
   

Romano J, Nimrod G, Ben-Tal N, Shadkchan Y, Baruch K, Sharon H, Osherov N. Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence. Microbiology. 2006 Jul;152(Pt 7):1919-28.
   

Willger SD, Grahl N, Cramer RA Jr. Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol. 2009;47 Suppl 1:S72-9. Epub 2009 Feb 27.
   

List last updated: July 2011 Back to top



Genomics and Proteomics

Andersen MR, Salazar MP, Schaap PJ, van de Vondervoort PJ, Culley D, Thykaer J, Frisvad JC, Nielsen KF, Albang R, Albermann K, Berka RM, Braus GH, Braus-Stromeyer SA, Corrochano LM, Dai Z, van Dijck PW, Hofmann G, Lasure LL, Magnuson JK, Menke H, Meijer M, Meijer SL, Nielsen JB, Nielsen ML, van Ooyen AJ, Pel HJ, Poulsen L, Samson RA, Stam H, Tsang A, van den Brink JM, Atkins A, Aerts A, Shapiro H, Pangilinan J, Salamov A, Lou Y, Lindquist E, Lucas S, Grimwood J, Grigoriev IV, Kubicek CP, Martinez D, van Peij NN, Roubos JA, Nielsen J, Baker SE. Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88. Genome Res. 2011 Jun;21(6):885-97. Epub 2011 May 4.
   

Baker SE. Aspergillus niger genomics: past, present and into the future. Med Mycol. 2006 Sep;44 Suppl 1:S17-21.
   

Braaksma M, Martens-Uzunova ES, Punt PJ, Schaap PJ. An inventory of the Aspergillus niger secretome by combining in silico predictions with shotgun proteomics data. BMC Genomics. 2010 Oct 19;11:584.
   

Jorgensen TR, Goosen T, Hondel CA, Ram AF, Iversen JJ. Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. BMC Genomics. 2009 Jan 23;10:44.
   

Jorgensen TR, Nitsche BM, Lamers GE, Arentshorst M, van den Hondel CA, Ram AF. Transcriptomic insights into the physiology of Aspergillus niger approaching a specific growth rate of zero. Appl Environ Microbiol. 2010 Aug;76(16):5344-55. Epub 2010 Jun 18.
   

Meyer V, Arentshorst M, Flitter SJ, Nitsche BM, Kwon MJ, Reynaga-Pena CG, Bartnicki-Garcia S, van den Hondel CA, Ram AF. Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics. Eukaryot Cell. 2009 Nov;8(11):1677-91. Epub 2009 Sep 11.
   

Meyer V, Damveld RA, Arentshorst M, Stahl U, van den Hondel CA, Ram AF. Survival in the presence of antifungals: genome-wide expression profiling of Aspergillus niger in response to sublethal concentrations of caspofungin and fenpropimorph. J Biol Chem. 2007 Nov 9;282(45):32935-48. Epub 2007 Sep 5.
   

Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H. Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol. 2007 Feb;25(2):221-31. Epub 2007 Jan 28.
   

Salazar M, Vongsangnak W, Panagiotou G, Andersen MR, Nielsen J. Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis. Mol Genet Genomics. 2009 Dec;282(6):571-86. Epub 2009 Sep 26.
   

Yuan XL, van der Kaaij RM, van den Hondel CA, Punt PJ, van der Maarel MJ, Dijkhuizen L, Ram AF. Aspergillus niger genome-wide analysis reveals a large number of novel alpha-glucan acting enzymes with unexpected expression profiles. Mol Genet Genomics. 2008 Jun;279(6):545-61. Epub 2008 Mar 5.
   

List last updated: August 2011 Back to top



Industrial Applications

Colin VL, Baigori MD, Pera LM. Mycelium-bound lipase production from Aspergillus niger MYA 135, and its potential applications for the transesterification of ethanol. J Basic Microbiol. 2011 Jun;51(3):236-42. doi: 10.1002/jobm.201000232. Epub 2011 Feb 7.
   

Driouch H, Sommer B, Wittmann C. Morphology engineering of Aspergillus niger for improved enzyme production. Biotechnol Bioeng. 2010 Apr 15;105(6):1058-68.
   

Fleissner A, Dersch P. Expression and export: recombinant protein production systems for Aspergillus. Appl Microbiol Biotechnol. 2010 Jul;87(4):1255-70. Epub 2010 Jun 8.
   

Gamarra NN, Villena GK, Gutierrez-Correa M. Cellulase production by Aspergillus niger in biofilm, solid-state, and submerged fermentations. Appl Microbiol Biotechnol. 2010 Jun;87(2):545-51. Epub 2010 Mar 31.
   

Jorgensen TR, Nielsen KF, Arentshorst M, Park J, van den Hondel CA, Frisvad JC, Ram AF. Submerged conidiation and product formation of Aspergillus niger at low specific growth rates is affected in aerial developmental mutants. Appl Environ Microbiol. 2011 Jun 7.
   

Karaffa L, Kubicek CP. Aspergillus niger citric acid accumulation: do we understand this well working black box? Appl Microbiol Biotechnol. 2003 May;61(3):189-96. Epub 2003 Jan 14.
   

Krull R, Cordes C, Horn H, Kampen I, Kwade A, Neu TR, Nortemann B. Morphology of Filamentous Fungi: Linking Cellular Biology to Process Engineering Using Aspergillus niger. Adv Biochem Eng Biotechnol. 2010;121:1-21.
   

List last updated: August 2011 Back to top



Molecular Tools

Carvalho ND, Arentshorst M, Jin Kwon M, Meyer V, Ram AF. Expanding the ku70 toolbox for filamentous fungi: establishment of complementation vectors and recipient strains for advanced gene analyses. Appl Microbiol Biotechnol. 2010 Jul;87(4):1463-73. Epub 2010 Apr 27.
   

Gordon CL, Archer DB, Jeenes DJ, Doonan JH, Wells B, Trinci AP, Robson GD. A glucoamylase::GFP gene fusion to study protein secretion by individual hyphae of Aspergillus niger. J Microbiol Methods. 2000 Sep;42(1):39-48.
   

Meyer V, Arentshorst M, El-Ghezal A, Drews AC, Kooistra R, van den Hondel CA, Ram AF. Highly efficient gene targeting in the Aspergillus niger kusA mutant. J Biotechnol. 2007 Mar 10;128(4):770-5. Epub 2007 Jan 10.
   

Meyer V, Wanka F, van Gent J, Arentshorst M, van den Hondel CA, Ram AF. Fungal gene expression on demand: an inducible, tunable, and metabolism-independent expression system for Aspergillus niger. Appl Environ Microbiol. 2011 May;77(9):2975-83. Epub 2011 Mar 4.
   

Swart K, Debets AJ, Bos CJ, Slakhorst M, Holub EF, Hoekstra RF. Genetic analysis in the asexual fungus Aspergillus niger. Acta Biol Hung. 2001;52(2-3):335-43.
   

List last updated: August 2011 Back to top



Morphology and Development

Bencina M, Legisa M, Read ND. Cross-talk between cAMP and calcium signalling in Aspergillus niger. Mol Microbiol. 2005 Apr;56(1):268-81.
   

Bowen AD, Davidson FA, Keatch R, Gadd GM. Induction of contour sensing in Aspergillus niger by stress and its relevance to fungal growth mechanics and hyphal tip structure. Fungal Genet Biol. 2007 Jun;44(6):484-91. Epub 2007 Jan 30.
   

Grimm LH, Kelly S, Hengstler J, Gobel A, Krull R, Hempel DC. Kinetic studies on the aggregation of Aspergillus niger conidia. Biotechnol Bioeng. 2004 Jul 20;87(2):213-8.
   

Grimm LH, Kelly S, Volkerding II, Krull R, Hempel DC. Influence of mechanical stress and surface interaction on the aggregation of Aspergillus niger conidia. Biotechnol Bioeng. 2005 Dec 30;92(7):879-88.
   

Krull R, Cordes C, Horn H, Kampen I, Kwade A, Neu TR, Nortemann B. Morphology of Filamentous Fungi: Linking Cellular Biology to Process Engineering Using Aspergillus niger. Adv Biochem Eng Biotechnol. 2010;121:1-21.
   

Kwon MJ, Arentshorst M, Roos ED, van den Hondel CA, Meyer V, Ram AF. Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi. Mol Microbiol. 2011 Mar;79(5):1151-67. doi: 10.1111/j.1365-2958.2010.07524.x. Epub 2011 Jan 18.
   

Meyer V, Arentshorst M, Flitter SJ, Nitsche BM, Kwon MJ, Reynaga-Pena CG, Bartnicki-Garcia S, van den Hondel CA, Ram AF. Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics. Eukaryot Cell. 2009 Nov;8(11):1677-91. Epub 2009 Sep 11.
   

Meyer V, Arentshorst M, van den Hondel CA, Ram AF. The polarisome component SpaA localises to hyphal tips of Aspergillus niger and is important for polar growth. Fungal Genet Biol. 2008 Feb;45(2):152-64. Epub 2007 Aug 3.
   

Meyer V, Minkwitz S, Schutze T, van den Hondel CA, Ram AF. The Aspergillus niger RmsA protein: A node in a genetic network? Commun Integr Biol. 2010 Mar;3(2):195-7.
   

Papagianni M, Mattey M. Morphological development of Aspergillus niger in submerged citric acid fermentation as a function of the spore inoculum level. Application of neural network and cluster analysis for characterization of mycelial morphology. Microb Cell Fact. 2006 Jan 25;5:3.
   

Reynaga-Pena CG, Gierz G, Bartnicki-Garcia S. Analysis of the role of the Spitzenkorper in fungal morphogenesis by computer simulation of apical branching in Aspergillus niger. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9096-101.
   

Vinck A, Terlou M, Pestman WR, Martens EP, Ram AF, van den Hondel CA, Wosten HA. Hyphal differentiation in the exploring mycelium of Aspergillus niger. Mol Microbiol. 2005 Nov;58(3):693-9.
   

List last updated: August 2011 Back to top



Mycotoxin Biosynthesis

Frisvad JC, Smedsgaard J, Samson RA, Larsen TO, Thrane U. Fumonisin B2 production by Aspergillus niger. J Agric Food Chem. 2007 Nov 14;55(23):9727-32. Epub 2007 Oct 12.
   

Jorgensen TR, Nielsen KF, Arentshorst M, Park J, van den Hondel CA, Frisvad JC, Ram AF. Submerged conidiation and product formation of Aspergillus niger at low specific growth rates is affected in aerial developmental mutants. Appl Environ Microbiol. 2011 Jun 7.
   

Nielsen KF, Mogensen JM, Johansen M, Larsen TO, Frisvad JC. Review of secondary metabolites and mycotoxins from the Aspergillus niger group. Anal Bioanal Chem. 2009 Nov;395(5):1225-42. Epub 2009 Sep 16.
   

Sorensen LM, Lametsch R, Andersen MR, Nielsen PV, Frisvad JC. Proteome analysis of Aspergillus niger: lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism. BMC Microbiol. 2009 Dec 10;9:255.
   

List last updated: August 2011 Back to top



Protein Secretion

Braaksma M, Martens-Uzunova ES, Punt PJ, Schaap PJ. An inventory of the Aspergillus niger secretome by combining in silico predictions with shotgun proteomics data. BMC Genomics. 2010 Oct 19;11:584.
   

Ferreira de Oliveira JM, van Passel MW, Schaap PJ, de Graaff LH. Shotgun proteomics of Aspergillus niger microsomes upon D-xylose induction. Appl Environ Microbiol. 2010 Jul;76(13):4421-9. Epub 2010 May 7.
   

Fleissner A, Dersch P. Expression and export: recombinant protein production systems for Aspergillus. Appl Microbiol Biotechnol. 2010 Jul;87(4):1255-70. Epub 2010 Jun 8.
   

Gordon CL, Archer DB, Jeenes DJ, Doonan JH, Wells B, Trinci AP, Robson GD. A glucoamylase::GFP gene fusion to study protein secretion by individual hyphae of Aspergillus niger. J Microbiol Methods. 2000 Sep;42(1):39-48.
   

Gordon CL, Khalaj V, Ram AF, Archer DB, Brookman JL, Trinci AP, Jeenes DJ, Doonan JH, Wells B, Punt PJ, van den Hondel CA, Robson GD. Glucoamylase::green fluorescent protein fusions to monitor protein secretion in Aspergillus niger. Microbiology. 2000 Feb;146 ( Pt 2):415-26.
   

Guillemette T, Ram AF, Carvalho ND, Joubert A, Simoneau P, Archer DB. Methods for investigating the UPR in filamentous fungi. Methods Enzymol. 2011;490:1-29.
   

Jorgensen TR, Goosen T, Hondel CA, Ram AF, Iversen JJ. Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. BMC Genomics. 2009 Jan 23;10:44.
   

Punt PJ, Veldhuisen G, van den Hondel CA. Protein targeting and secretion in filamentous fungi. A progress report. Antonie Van Leeuwenhoek. 1994;65(3):211-6.
   

List last updated: August 2011 Back to top



Selected Topics in Aspergillus oryzae Biology



Conidiation

Hatakeyama R, Nakahama T, Higuchi Y, Kitamoto K. Light represses conidiation in koji mold Aspergillus oryzae. Biosci Biotechnol Biochem. 2007 Aug;71(8):1844-9. Epub 2007 Aug 7.
   

Ogawa M, Tokuoka M, Jin FJ, Takahashi T, Koyama Y. Genetic analysis of conidiation regulatory pathways in koji-mold Aspergillus oryzae. Fungal Genet Biol. 2010 Jan;47(1):10-8. Epub
   

List last updated: November 2011 Back to top



Genomics

Abe K, Gomi K, Hasegawa F, Machida M. Impact of Aspergillus oryzae genomics on industrial production of metabolites. Mycopathologia. 2006 Sep;162(3):143-53.
   

Khaldi N, Wolfe KH. Elusive origins of the extra genes in Aspergillus oryzae. PLoS One. 2008 Aug 22;3(8):e3036.
   

Kobayashi T, Abe K, Asai K, Gomi K, Juvvadi PR, Kato M, Kitamoto K, Takeuchi M, Machida M. Genomics of Aspergillus oryzae. Biosci Biotechnol Biochem. 2007 Mar;71(3):646-70. Epub 2007 Mar 7.
   

Machida M. Progress of Aspergillus oryzae genomics. Adv Appl Microbiol. 2002;51:81-106.
   

Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman WC, Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H. Genome sequencing and analysis of Aspergillus oryzae. Nature. 2005 Dec 22;438(7071):1157-61.
   


Machida M, Terabayashi Y, Sano M, Yamane N, Tamano K, Payne GA, Yu J, Cleveland TE, Nierman WC. Genomics of industrial Aspergilli and comparison with toxigenic relatives. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Sep;25(9):1147-51.
   

Machida M, Yamada O, Gomi K. Genomics of Aspergillus oryzae: learning from the history of Koji mold and exploration of its future. DNA Res. 2008 Aug;15(4):173-83.
   

Maeda H, Sano M, Maruyama Y, Tanno T, Akao T, Totsuka Y, Endo M, Sakurada R, Yamagata Y, Machida M, Akita O, Hasegawa F, Abe K, Gomi K, Nakajima T, Iguchi Y. Transcriptional analysis of genes for energy catabolism and hydrolytic enzymes in the filamentous fungus Aspergillus oryzae using cDNA microarrays and expressed sequence tags. Appl Microbiol Biotechnol. 2004 Jul;65(1):74-83. Epub 2004 May 20.
   

Vongsangnak W, Hansen K, Nielsen J. Integrated analysis of the global transcriptional response to alpha-amylase over-production by Aspergillus oryzae. Biotechnol Bioeng. 2011 May;108(5):1130-9. doi: 10.1002/bit.23033. Epub 2010 Dec 28.
   

Vongsangnak W, Nookaew I, Salazar M, Nielsen J. Analysis of genome-wide coexpression and coevolution of Aspergillus oryzae and Aspergillus niger. OMICS. 2010 Apr;14(2):165-75.
   

Vongsangnak W, Olsen P, Hansen K, Krogsgaard S, Nielsen J. Improved annotation through genome-scale metabolic modeling of Aspergillus oryzae. BMC Genomics. 2008 May 23;9:245.
   




Wang B, Guo G, Wang C, Lin Y, Wang X, Zhao M, Guo Y, He M, Zhang Y, Pan L. Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing. Nucleic Acids Res. 2010 Aug;38(15):5075-87. Epub 2010 Apr 14.
   

List last updated: November 2011 Back to top



Growth and Cultivation

Haack MB, Olsson L, Hansen K, Eliasson Lantz A. Change in hyphal morphology of Aspergillus oryzae during fed-batch cultivation. Appl Microbiol Biotechnol. 2006 Apr;70(4):482-7. Epub 2005 Aug 30.
   

Imanaka H, Tanaka S, Feng B, Imamura K, Nakanishi K. Cultivation characteristics and gene expression profiles of Aspergillus oryzae by membrane-surface liquid culture, shaking-flask culture, and agar-plate culture. J Biosci Bioeng. 2010 Mar;109(3):267-73. Epub 2009 Oct 6
   

List last updated: November 2011 Back to top



Molecular Tools

Elrod SL, Jones A, Berka RM, Cherry JR. Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker. Curr Genet. 2000 Dec;38(5):291-8.
   

Ishida H, Hata Y, Kawato A, Abe Y. Improvement of the glaB promoter expressed in solid-state fermentation (SSF) of Aspergillus oryzae. Biosci Biotechnol Biochem. 2006 May;70(5):1181-7.
   

Ishida H, Hata Y, Kawato A, Abe Y, Kashiwagi Y. Isolation of a novel promoter for efficient protein production in Aspergillus oryzae. Biosci Biotechnol Biochem. 2004 Sep;68(9):1849-57.
   

Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K. Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts. Biosci Biotechnol Biochem. 2004 Mar;68(3):656-62.
   


Maruyama J, Kitamoto K. Multiple gene disruptions by marker recycling with highly efficient gene-targeting background (DeltaligD) in Aspergillus oryzae. Biotechnol Lett. 2008 Oct;30(10):1811-7. Epub 2008 Jun 24.
   

Mizutani O, Kudo Y, Saito A, Matsuura T, Inoue H, Abe K, Gomi K A defect of LigD (human Lig4 homolog) for nonhomologous end joining significantly improves efficiency of gene-targeting in Aspergillus oryzae. Fungal Genet Biol. 2008 Jun;45(6):878-89. Epub 2008 Jan 11.
   

Takahashi T, Masuda T, Koyama Y. Enhanced gene targeting frequency in ku70 and ku80 disruption mutants of Aspergillus sojae and Aspergillus oryzae. Mol Genet Genomics. 2006 May;275(5):460-70. Epub 2006 Feb 10.
   

Yamada O, Ikeda R, Ohkita Y, Hayashi R, Sakamoto K, Akita O. Gene silencing by RNA interference in the koji mold Aspergillus oryzae. Biosci Biotechnol Biochem. 2007 Jan;71(1):138-44. Epub 2007 Jan 7.
   

List last updated: November 2011 Back to top



Other Topics

Ishitani C, Sakaguchi K. Hereditary variation and genetic recombination in Koji-molds (Aspergillus oryzae and Asp. sojae). I. Natural variation. J Gen Appl Microbiol. 2004 Dec;50(6):315-26.
   

Kitamoto K. Molecular biology of the Koji molds. Adv Appl Microbiol. 2002;51:129-53.
   

List last updated: November 2011 Back to top



Protease Production

Yoon J, Maruyama J, Kitamoto K. Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins. Appl Microbiol Biotechnol. 2011 Feb;89(3):747-59. Epub 2010 Oct 19.
   

List last updated: November 2011 Back to top



Protein Secretion

Fleissner A, Dersch P. Expression and export: recombinant protein production systems for Aspergillis. Appl Microbiol Biotechnol. 2010 Jul;87(4):1255-70. Epub 2010 Jun 8.
   

Ishida H, Hata Y, Kawato A, Abe Y, Kashiwagi Y. Isolation of a novel promoter for efficient protein production in Aspergillus oryzae. Biosci Biotechnol Biochem. 2004 Sep;68(9):1849-57.
   

Yoon J, Aishan T, Maruyama J, Kitamoto K. Enhanced production and secretion of heterologous proteins by the filamentous fungus Aspergillus oryzae via disruption of vacuolar protein sorting receptor gene Aovps10. Appl Environ Microbiol. 2010 Sep;76(17):5718-27. Epub 2010 Jul 9.
   

Yoon J, Maruyama J, Kitamoto K. Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins. Appl Microbiol Biotechnol. 2011 Feb;89(3):747-59. Epub 2010 Oct 19.
   

List last updated: November 2011 Back to top



Toxin Production

Terabayashi Y, Sano M, Yamane N, Marui J, Tamano K, Sagara J, Dohmoto M, Oda K, Ohshima E, Tachibana K, Higa Y, Ohashi S, Koike H, Machida M. Identification and characterization of genes responsible for biosynthesis of kojic acid, an industrially important compound from Aspergillus oryzae. Fungal Genet Biol. 2010 Dec;47(12):953-61. Epub 2010 Sep 16.
   

Tominaga M, Lee YH, Hayashi R, Suzuki Y, Yamada O, Sakamoto K, Gotoh K, Akita O. Molecular analysis of an inactive aflatoxin biosynthesis gene cluster in Aspergillus oryzae RIB strains. Appl Environ Microbiol. 2006 Jan;72(1):484-90.
   

List last updated: November 2011 Back to top



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