A. nidulans flbD/AN0279 Summary

Summary

Locus History

flbD BASIC INFORMATION [ View References ]

Standard Name

flbD¹

Systematic Name, Reference Strain

AN0279 (A. nidulans FGSC A4)

Alias

ANID_00279, ANIA_00279

Feature Type

ORF, Verified

Description

Putative transcription factor involved in regulation of asexual and sexual development and in response to nitrogen starvation; contains a myb-like DNA-binding domain (1, 2)

Literature

Name Description

Fluffy Low BrlA expression³

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090005000765
A. fumigatus Af293 Ortholog(s) : Afu1g03210/flbD
A. niger CBS 513.88 Ortholog(s) : An01g04830/flbD
View ortholog cluster : 21 genes among 21 Aspergillus-related species/strains
View alignment

Best hit(s) in non-AspGD species

N. crassa (rca-1) ; C. albicans (C2_05640W_A) ; S. pombe (cdc5) ; S. cerevisiae (BAS1)

Chromosomal Location

GBrowse for A. nidulans FGSC A4
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AN0279

GO Annotations		View all flbD GO evidence and references
Molecular Function
Manually curated		transcription factor activity, sequence-specific DNA binding (ISS) transcription regulatory region DNA binding (IDA)
Computational		chromatin binding (IEA with EBI: IPR001005)
Biological Process
Manually curated		cellular response to nitrogen starvation (IMP) cleistothecium development (IMP) conidium formation (IMP) positive regulation of conidium formation (IMP) regulation of transcription from RNA polymerase II promoter (ISS)
Cellular Component
Manually curated		nucleus (IDA)

Mutant Phenotype		View all flbD Phenotype details and references
Classical genetics
null		flbB mRNA accumulation: decreased colony appearance: abnormal conidiation: decreased hyphal growth: abnormal viable
overexpression		brlA mRNA accumulation: increased conidiation: increased
reduction of function		conidiation: decreased formation of cleistothecium: abnormal
unspecified		brlA(p)-lacZ activity: decreased

Sequence Information

ChrVIII_A_nidulans_FGSC_A4:4060950 to 4061894 | GBrowse

Last Update

Coordinates: 2009-03-03 | Sequence: 2009-03-03

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-214	to	-1	4,060,736	to	4,060,949	2012-08-30	2012-08-30
CDS	1	to	945	4,060,950	to	4,061,894	2009-03-03	2009-03-03
3' UTR	946	to	1299	4,061,895	to	4,062,248	2012-08-30	2012-08-30

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

External Links

Primary AspGDID

ASPL0000052812

ADDITIONAL INFORMATION for flbD

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for flbD

Description from CADRE : Myb-like DNA binding domain transcription factor, FlbD, involved in conidiophore development

GO terms assigned by Eurofung/TIGR:
- transcription factor activity (GO:0003700), ISS, with Pfam:PF00249, PMID:7883170, Assigned by: Eurofung

Notes from Eurofung/TIGR GO annotation:
Clutterbuck: Contains Mariner-2_AN 52 nt fragment (Kapitonov & Jurka 2003 RepBase reports 3;195) co-ordinates 402115-402063

Last Updated: 2010-07-06

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for flbD]

1)	Wieser J and Adams TH (1995) flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development. Genes Dev 9(4):491-502
2)	*Arratia-Quijada J, et al.* (2012)** FlbD, a Myb transcription factor of Aspergillus nidulans, is uniquely involved in both asexual and sexual differentiation. Eukaryot Cell 11(9):1132-42
3)	*Wieser J, et al.* (1994)** Genetic requirements for initiating asexual development in Aspergillus nidulans. Curr Genet 27(1):62-9

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