A. nidulans brlA/AN0973 Summary

Summary

Locus History

brlA BASIC INFORMATION [ View References ]

Standard Name

brlA¹

Systematic Name, Reference Strain

AN0973 (A. nidulans FGSC A4)

Alias

brl², br², ANID_00973, ANIA_00973

Feature Type

ORF, Verified

Description

C2H2 zinc finger transcription factor, fphA- and lreB-dependent light induced regulator of conidiophore development; locus has 2 overlapping transcriptional units called brlA alpha and brlA beta; see 5' brlA micro-ORF, AN0974 (1, 3, 4, 5, 6)

Literature

Name Description

BRistLe⁷

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090005001041/brlA
A. fumigatus Af293 Ortholog(s) : Afu1g16590/brlA
A. niger CBS 513.88 Ortholog(s) : An01g10540/brlA
View ortholog cluster : 21 genes among 21 Aspergillus-related species/strains
View alignment

Best hit(s) in non-AspGD species

N. crassa (pp-1) ; C. albicans (CAS5) ; S. pombe (scr1) ; S. cerevisiae (MSN4)

Chromosomal Location

GBrowse for A. nidulans FGSC A4
Click on map for expanded view
AN0973

GO Annotations		View all brlA GO evidence and references
Molecular Function
Manually curated		transcription factor activity, sequence-specific DNA binding (IDA)
Computational		nucleic acid binding (IEA with EBI: IPR013087)
Biological Process
Manually curated		autolysis (IMP) conidium formation (IMP) positive regulation of conidium formation (IMP, IEP) regulation of secondary metabolite biosynthetic process (IMP) regulation of sterigmatocystin biosynthetic process (IMP) regulation of transcription from RNA polymerase II promoter (IMP, IDA) response to starvation (IEP) sporocarp development involved in asexual reproduction (IMP) sterigmatocystin biosynthetic process (IMP)
Computational		alkaloid biosynthetic process (IEA with A. fumigatus: brlA) asexual sporulation resulting in formation of a cellular spore (IEA with A. fumigatus: brlA, A. niger: brlA) conidiophore stalk development (IEA with A. niger: brlA) melanin biosynthetic process (IEA with A. fumigatus: brlA) positive regulation of asexual sporulation resulting in formation of a cellular spore (IEA with A. fumigatus: brlA) positive regulation of melanin biosynthetic process (IEA with A. fumigatus: brlA)
Cellular Component
Manually curated		cellular_component unknown (ND)

Mutant Phenotype		View all brlA Phenotype details and references
Classical genetics
activation		sterigmatocystin production: decreased
conditional		steA mRNA accumulation: increased conidiation: absent NimA kinase activity: decreased NimX kinase activity: decreased chsC::lacZ activity: decreased
misexpression		abaA mRNA accumulation: increased wetA mRNA accumulation: increased conidiation: abnormal hyphal growth: abnormal NimA kinase activity: increased NimX kinase activity: increased vegetative growth: decreased rate
null		autolysis: decreased liquid culture appearance: abnormal chitinase activity: decreased
overexpression		conidial germination: absent
reduction of function		conidiation: abnormal
unspecified		steA mRNA accumulation: increased conidiation: abnormal conidiation: absent conidiation: decreased StuA:beta-Gal activity: decreased alpha-1,3 glucanase activity: decreased laminarinase activity: decreased conidiophore pigment accumulation: decreased

Sequence Information

ChrVIII_A_nidulans_FGSC_A4:1925003 to 1926301 | GBrowse

Last Update

Coordinates: 2009-03-03 | Sequence: 2009-03-03

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-334	to	-1	1,924,669	to	1,925,002	2012-08-30	2012-08-30
CDS	1	to	1299	1,925,003	to	1,926,301	2009-03-03	2009-03-03
3' UTR	1300	to	2040	1,926,302	to	1,927,042	2012-08-30	2012-08-30

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

External Links

Primary AspGDID

ASPL0000057402

ADDITIONAL INFORMATION for brlA

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for brlA

Description from CADRE : BrlA, C2H2 finger domain transcription factor

GO terms assigned by Eurofung/TIGR:
- transcription factor activity (GO:0003700), IDA, PMID:8417986, Assigned by: Eurofung
- zinc ion binding (GO:0008270), ISS, with Pfam:PF00096, PMID:3293800, Assigned by: Eurofung
- response to osmotic stress (GO:0006970), IMP, with NCBI_gi:1870218, PMID:8617205, Assigned by: Eurofung
- response to starvation (GO:0042594), IMP, with NCBI_gi:1870218, PMID:7894714, Assigned by: Eurofung

Notes from Eurofung/TIGR GO annotation:
turner: Regulator of asexual development. Necessary for conidiophore development. bristle.

Last Updated: 2010-07-06

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for brlA]

1)	*Adams TH, et al.* (1988)** brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54(3):353-62
2)	Clutterbuck AJ (1994) Linkage map and locus list. Prog Ind Microbiol 29:791-824
3)	Chang YC and Timberlake WE (1993) Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast. Genetics 133(1):29-38
4)	*Han S, et al.* (1993)** Translational repression of brlA expression prevents premature development in Aspergillus. EMBO J 12(6):2449-57
5)	Prade RA and Timberlake WE (1993) The Aspergillus nidulans brlA regulatory locus consists of overlapping transcription units that are individually required for conidiophore development. EMBO J 12(6):2439-47
6)	*Ruger-Herreros C, et al.* (2011)** Regulation of conidiation by light in Aspergillus nidulans. Genetics 188(4):809-22
7)	Clutterbuck AJ (1969) A mutational analysis of conidial development in Aspergillus nidulans. Genetics 63(2):317-27

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