A. nidulans sirA/AN10449 Summary

Summary

Locus History

sirA BASIC INFORMATION [ View References ]

Standard Name

sirA¹

Systematic Name, Reference Strain

AN10449 (A. nidulans FGSC A4)

Alias

ANID_10449, ANIA_10449

Feature Type

ORF, Verified

Description

Sir2 ortholog; NAD-dependent histone deacetylase (H4-K16 specific), tetra-acetyl histone H4 deacetylase; regulates H4K16 acetylation and secondary metabolite production through its H4K16-deacetylating activity (1)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090003000996
A. fumigatus Af293 Ortholog(s) : Afu4g12120
A. niger CBS 513.88 Ortholog(s) : An01g07390
View ortholog cluster : 13 genes among 13 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (nst-1) ; C. albicans (HST1) ; S. pombe (sir2) ; S. cerevisiae (HST1)

Chromosomal Location

GBrowse for A. nidulans FGSC A4
Click on map for expanded view
AN10449

GO Annotations		View all sirA GO evidence and references
Molecular Function
Manually curated		NAD-dependent histone deacetylase activity (H4-K16 specific) (IMP)
Computational		NAD+ binding (IEA with S. pombe: sir2) NAD-dependent histone deacetylase activity (H3-K9 specific) (IEA with S. pombe: sir2) NAD-independent histone deacetylase activity (IEA with S. cerevisiae: HST1) histone deacetylase activity (H3-K14 specific) (IEA with S. pombe: sir2) histone deacetylase activity (H3-K4 specific) (IEA with S. pombe: sir2)
Biological Process
Computational		chromatin silencing at centromere outer repeat region (IEA with S. pombe: sir2) chromatin silencing at silent mating-type cassette (IEA with S. cerevisiae: HST1, S. pombe: sir2) chromatin silencing at telomere (IEA with S. pombe: sir2, N. crassa: nst-1) histone H3-K4 deacetylation (IEA with S. pombe: sir2) histone H3-K9 deacetylation (IEA with S. pombe: sir2) histone H4-K12 deacetylation (IEA with S. pombe: sir2) histone H4-K16 deacetylation (IEA with S. pombe: sir2) negative regulation of mitotic recombination (IEA with S. cerevisiae: HST1) phenotypic switching (IEA with C. albicans: HST1) protein localization to chromosome, telomeric region (IEA with S. pombe: sir2) regulation of histone H3-K9 methylation (IEA with S. pombe: sir2)
Cellular Component
Computational		Set3 complex (IEA with S. cerevisiae: HST1) mating-type region heterochromatin (IEA with S. pombe: sir2) nuclear pericentric heterochromatin (IEA with S. pombe: sir2) nuclear rDNA heterochromatin (IEA with S. pombe: sir2) nuclear subtelomeric heterochromatin (IEA with S. pombe: sir2)

Mutant Phenotype		View all sirA Phenotype details and references
Classical genetics
null		H4K16 acetylation accumulation: decreased penicillin production: decreased sterigmatocystin production: decreased viable

Sequence Information

ChrII_A_nidulans_FGSC_A4:3500631 to 3498940 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2011-12-16 | Sequence: 2009-03-02

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-78	to	-1	3,500,709	to	3,500,632	2012-08-30	2012-08-30
CDS	1	to	241	3,500,631	to	3,500,391	2011-12-16	2009-03-02
Intron	242	to	307	3,500,390	to	3,500,325	2011-12-16	2009-03-02
CDS	308	to	621	3,500,324	to	3,500,011	2011-12-16	2009-03-02
Intron	622	to	671	3,500,010	to	3,499,961	2011-12-16	2009-03-02
CDS	672	to	1226	3,499,960	to	3,499,406	2011-12-16	2009-03-02
Intron	1227	to	1281	3,499,405	to	3,499,351	2011-12-16	2009-03-02
CDS	1282	to	1461	3,499,350	to	3,499,171	2011-12-16	2009-03-02
Intron	1462	to	1512	3,499,170	to	3,499,120	2011-12-16	2009-03-02
CDS	1513	to	1692	3,499,119	to	3,498,940	2011-12-16	2009-03-02
3' UTR	1693	to	1952	3,498,939	to	3,498,680	2012-08-30	2012-08-30

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

External Links

Primary AspGDID

ASPL0000015376

ADDITIONAL INFORMATION for sirA

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for sirA

Description from CADRE : histone deacetylase

Last Updated: 2010-07-06

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for sirA]

1)	*Shimizu M, et al.* (2012)** Hydrolase controls cellular NAD, sirtuin, and secondary metabolites. Mol Cell Biol 32(18):3743-55

Return to AspGD

AspGD Copyright © 2008-2017 The Board of Trustees, Leland Stanford Junior University.
Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied.
To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.