A. nidulans atfA/AN2911 Summary

Summary

Locus History

atfA BASIC INFORMATION [ View References ]

Standard Name

atfA¹

Systematic Name, Reference Strain

AN2911 (A. nidulans FGSC A4)

Alias

ANID_02911, ANIA_02911

Feature Type

ORF, Verified

Description

Basic-region leucine zipper transcription factor; plays a role in the response of conidia to stress; expression upregulated after exposure to farnesol (1, 2)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090003000685/atfA
A. fumigatus Af293 Ortholog(s) : Afu3g11330/atfA
A. niger CBS 513.88 Ortholog(s) : An02g07070
View ortholog cluster : 21 genes among 21 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (asl-1) ; S. pombe (atf1)

Best hit(s) in non-AspGD species

C. albicans (SKO1) ; S. cerevisiae (SKO1)

Chromosomal Location

GBrowse for A. nidulans FGSC A4
Click on map for expanded view
AN2911

GO Annotations		View all atfA GO evidence and references
Molecular Function
Computational		RNA binding (IEA with S. pombe: atf1) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IEA with S. pombe: atf1) recombination hotspot binding (IEA with S. pombe: atf1) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (IEA with S. pombe: atf1)
Biological Process
Manually curated		cellular response to heat (IMP) cellular response to oxidative stress (IMP, IGI with A. nidulans: hogA)
Computational		activation of reciprocal meiotic recombination (IEA with S. pombe: atf1) conidium formation (IEA with N. crassa: asl-1) mitotic G1 cell cycle arrest in response to nitrogen starvation (IEA with S. pombe: atf1) negative regulation of antisense RNA transcription (IEA with S. pombe: atf1) negative regulation of reciprocal meiotic recombination (IEA with S. pombe: atf1) negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress (IEA with S. pombe: atf1) nucleosome positioning (IEA with S. pombe: atf1) osmosensory signaling pathway (IEA with S. pombe: atf1) positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation (IEA with S. pombe: atf1) positive regulation of transcription from RNA polymerase II promoter in response to maltose (IEA with S. pombe: atf1) protein localization to nucleus (IEA with S. pombe: atf1) reciprocal meiotic recombination (IEA with S. pombe: atf1) regulation of cAMP-mediated signaling (IEA with S. pombe: atf1) spore germination (IEA with N. crassa: asl-1) stress-activated MAPK cascade (IEA with S. pombe: atf1)
Cellular Component
Manually curated		nucleus (IDA)
Computational		atf1-pcr1 complex (IEA with S. pombe: atf1) nuclear chromatin (IEA with S. pombe: atf1)

Mutant Phenotype		View all atfA Phenotype details and references
Classical genetics
null		catA mRNA accumulation: decreased gfdB mRNA accumulation: decreased cold sensitivity: increased conidial germination: decreased heat sensitivity: increased oxidative stress resistance: decreased resistance to tert-butylhydroperoxide: decreased viable

Sequence Information

ChrVI_A_nidulans_FGSC_A4:2426194 to 2424440 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-03-03 | Sequence: 2009-03-03

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-106	to	-1	2,426,300	to	2,426,195	2012-08-30	2012-08-30
CDS	1	to	106	2,426,194	to	2,426,089	2009-03-03	2009-03-03
Intron	107	to	350	2,426,088	to	2,425,845	2009-03-03	2009-03-03
CDS	351	to	1482	2,425,844	to	2,424,713	2009-03-03	2009-03-03
Intron	1483	to	1535	2,424,712	to	2,424,660	2009-03-03	2009-03-03
CDS	1536	to	1755	2,424,659	to	2,424,440	2009-03-03	2009-03-03
3' UTR	1756	to	1948	2,424,439	to	2,424,247	2012-08-30	2012-08-30

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

External Links

Primary AspGDID

ASPL0000040171

ADDITIONAL INFORMATION for atfA

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for atfA

Description from CADRE : atfA, putative b-zip transcription factor.

GO terms assigned by Eurofung/TIGR:
- DNA binding (GO:0003677), ISS, with Pfam: PF00170, Assigned by: TIGR
- nucleus (GO:0005634), ISS, with Pfam: PF00170, Assigned by: TIGR
- regulation of transcription, DNA-dependent (GO:0006355), ISS, with Pfam: PF00170, Assigned by: TIGR

Last Updated: 2010-07-06

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for atfA]

1)	*Hagiwara D, et al.* (2008)** Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans. Biosci Biotechnol Biochem 72(10):2756-60
2)	*Savoldi M, et al.* (2008)** Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. Mol Microbiol 70(1):44-59

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