A. nidulans flbB/AN7542 Summary

Summary

Locus History

flbB BASIC INFORMATION [ View References ]

Standard Name

flbB¹

Systematic Name, Reference Strain

AN7542 (A. nidulans FGSC A4)

Alias

vegA¹
ANID_07542, ANIA_07542

Feature Type

ORF, Verified

Description

Basic leucine zipper transcription factor involved in regulation of conidiophore development; localizes to the most apical nucleus and the tip of mature vegetative hyphae; required for light-dependent activation of brlA transcription (1, 2, 3)

Literature

Name Description

Fluffy Low BrlA expression⁴

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090026000810
A. fumigatus Af293 Ortholog(s) : Afu2g14680/flbB
A. niger CBS 513.88 Ortholog(s) : An15g03710
View ortholog cluster : 21 genes among 21 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (NCU07379)

Best hit(s) in non-AspGD species

S. pombe (pap1)

Chromosomal Location

GBrowse for A. nidulans FGSC A4
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AN7542

GO Annotations		View all flbB GO evidence and references
Molecular Function
Manually curated		DNA binding (IDA) transcription factor activity, sequence-specific DNA binding (ISM, IDA) transcription regulatory region DNA binding (IDA)
Computational		sequence-specific DNA binding (IEA with EBI: IPR004827)
Biological Process
Manually curated		conidium formation (IMP) positive regulation of conidium formation (IMP) regulation of transcription from RNA polymerase II promoter (IDA, ISM, IMP)
Computational		asexual sporulation resulting in formation of a cellular spore (IEA with A. fumigatus: flbB)
Cellular Component
Manually curated		hyphal tip (IDA, IPI with A. nidulans: flbE) nucleus (IDA)

Mutant Phenotype		View all flbB Phenotype details and references
Classical genetics
misexpression		formation of conidiophore: abnormal
null		brlA mRNA accumulation: decreased flbD mRNA accumulation: decreased autolysis: increased colony appearance: abnormal conidiation: absent hyphal growth: abnormal FlbD accumulation: decreased viable
overexpression		conidiation: decreased
unspecified		conidiation: delayed brlA(p)-lacZ activity: decreased

Sequence Information

ChrIV_A_nidulans_FGSC_A4:1891629 to 1890006 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-03-04 | Sequence: 2009-03-04

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-345	to	-246	1,891,974	to	1,891,875	2012-08-30	2012-08-30
5' UTR intron	-245	to	-140	1,891,874	to	1,891,769	2012-08-30	2012-08-30
5' UTR	-139	to	-1	1,891,768	to	1,891,630	2012-08-30	2012-08-30
CDS	1	to	91	1,891,629	to	1,891,539	2009-03-04	2009-03-04
Intron	92	to	291	1,891,538	to	1,891,339	2009-03-04	2009-03-04
CDS	292	to	384	1,891,338	to	1,891,246	2009-03-04	2009-03-04
Intron	385	to	433	1,891,245	to	1,891,197	2009-03-04	2009-03-04
CDS	434	to	521	1,891,196	to	1,891,109	2009-03-04	2009-03-04
Intron	522	to	567	1,891,108	to	1,891,063	2009-03-04	2009-03-04
CDS	568	to	1095	1,891,062	to	1,890,535	2009-03-04	2009-03-04
Intron	1096	to	1143	1,890,534	to	1,890,487	2009-03-04	2009-03-04
CDS	1144	to	1624	1,890,486	to	1,890,006	2009-03-04	2009-03-04
3' UTR	1625	to	1846	1,890,005	to	1,889,784	2009-12-15	2009-12-15

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

External Links

Primary AspGDID

ASPL0000064455

ADDITIONAL INFORMATION for flbB

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for flbB

Description from CADRE : flbB, b-zip transcription factor

Last Updated: 2010-07-06

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for flbB]

1)	*Etxebeste O, et al.* (2008)** Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans. Eukaryot Cell 7(1):38-48
2)	*Etxebeste O, et al.* (2009)** The bZIP-type transcription factor FlbB regulates distinct morphogenetic stages of colony formation in Aspergillus nidulans. Mol Microbiol 73(5):775-89
3)	*Ruger-Herreros C, et al.* (2011)** Regulation of conidiation by light in Aspergillus nidulans. Genetics 188(4):809-22
4)	*Wieser J, et al.* (1994)** Genetic requirements for initiating asexual development in Aspergillus nidulans. Curr Genet 27(1):62-9

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