A. fumigatus velB/Afu1g01970 Summary

Summary

Locus History

velB BASIC INFORMATION [ View References ]

Standard Name

velB¹

Systematic Name, Reference Strain

Afu1g01970 (A. fumigatus Af293)

Alias

AFUA_1G01970, CADAFUAG00008706²

Systematic Names Used in Other Strains

AFUB_002350 (A. fumigatus A1163)

Feature Type

ORF, Verified

Description

Velvet family protein; role in negative regulation of conidium formation and conidial germination; trehalose biosynthesis; resistence to UV and H2O2 stress; transcript high in conidia, during late phase of conidiation and in mature conidia (1)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090005000898
A. nidulans FGSC A4 Ortholog(s) : AN0363/velB
View ortholog cluster : 20 genes among 20 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (NCU02775)

Best hits in Aspergillus species

A. niger CBS 513.88 best hit(s) : An01g06290/velB

Chromosomal Location

GBrowse for A. fumigatus Af293
Click on map for expanded view
Afu1g01970

GO Annotations		View all velB GO evidence and references
Molecular Function
Manually curated		molecular_function unknown (ND)
Biological Process
Manually curated		cellular response to UV (IMP) cellular response to hydrogen peroxide (IMP) conidiophore development (IMP) negative regulation of conidiophore development (IMP) negative regulation of sexual sporulation resulting in formation of a cellular spore (IMP) spore germination (IMP) trehalose biosynthetic process (IMP)
Computational		conidium formation (IEA with A. nidulans: velB) negative regulation of conidium formation (IEA with A. nidulans: velB) positive regulation of sexual sporulation resulting in formation of a cellular spore (IEA with A. nidulans: velB) positive regulation of sterigmatocystin biosynthetic process (IEA with A. nidulans: velB) sexual sporulation resulting in formation of a cellular spore (IEA with A. nidulans: velB) sterigmatocystin biosynthetic process (IEA with A. nidulans: velB)
Cellular Component
Computational		cytoplasm (IEA with A. nidulans: velB) nucleus (IEA with A. nidulans: velB)

Mutant Phenotype		View all velB Phenotype details and references
Classical genetics
null		UV resistance: decreased trehalose accumulation: increased colony color: abnormal colony size: decreased conidial germination: increased rate conidiation: increased rate oxidative stress resistance: decreased viable

Sequence Information

Chr1_A_fumigatus_Af293:586992 to 588246 | GBrowse

Last Update

Coordinates: 2011-01-07 | Sequence: 2011-01-07

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-2202	to	-1	584,790	to	586,991	2015-08-20	2015-08-20
CDS	1	to	228	586,992	to	587,219	2011-01-07	2011-01-07
Intron	229	to	292	587,220	to	587,283	2011-01-07	2011-01-07
CDS	293	to	372	587,284	to	587,363	2011-01-07	2011-01-07
Intron	373	to	430	587,364	to	587,421	2011-01-07	2011-01-07
CDS	431	to	916	587,422	to	587,907	2011-01-07	2011-01-07
Intron	917	to	978	587,908	to	587,969	2011-01-07	2011-01-07
CDS	979	to	1255	587,970	to	588,246	2011-01-07	2011-01-07
3' UTR	1256	to	1658	588,247	to	588,649	2013-03-13	2013-03-13

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

Sequence Variation

External Links

CADRE | FungiDB | GenBank (1, 2, 3, 4) | TrEMBL

Primary AspGDID

ASPL0000101367

ADDITIONAL INFORMATION for velB

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for velB

Name listed in the Broad Institute genome_summary_per_gene_file: mutant VeA1 protein

Last Updated: 2010-08-25

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for velB]

1)	*Park HS, et al.* (2012)** Characterization of the velvet regulators in Aspergillus fumigatus. Mol Microbiol 86(4):937-53
2)	AspGD (2012) Update of Aspergillus fumigatus Af293 reference annotation

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To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.