A. fumigatus tor/Afu2g10270 Summary

Summary

Locus History

tor BASIC INFORMATION [ View References ]

Standard Name

tor¹

Systematic Name, Reference Strain

Afu2g10270 (A. fumigatus Af293)

Alias

AFUA_2G10270, CADAFUAG00004267²

Systematic Names Used in Other Strains

AFUB_026080 (A. fumigatus A1163)

Feature Type

ORF, Uncharacterized

Description

Tor kinase, involved in regulation cell wall biosynthesis and nutrient sensing (1)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090011000608
A. nidulans FGSC A4 Ortholog(s) : AN5982/torA
A. niger CBS 513.88 Ortholog(s) : An16g04720
View ortholog cluster : 22 genes among 21 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (NCU05608) ; S. pombe (tor2)

Best hit(s) in non-AspGD species

C. albicans (TOR1) ; S. cerevisiae (TOR2)

Chromosomal Location

GBrowse for A. fumigatus Af293
Click on map for expanded view
Afu2g10270

GO Annotations		View all tor GO evidence and references
Molecular Function
Computational		drug binding (IEA with EBI: IPR009076) macromolecular complex binding (IEA with EBI: IPR009076) protein serine/threonine kinase activity (IEA with S. pombe: tor2)
Biological Process
Computational		TORC1 signaling (IEA with S. pombe: tor2) mitotic G1 cell cycle arrest in response to nitrogen starvation (IEA with S. pombe: tor2) negative regulation of autophagy (IEA with S. pombe: tor2) negative regulation of induction of conjugation with cellular fusion (IEA with S. pombe: tor2) positive regulation of cell size (IEA with S. pombe: tor2) positive regulation of mitotic cell cycle (IEA with S. pombe: tor2)
Cellular Component
Computational		TORC1 complex (IEA with S. pombe: tor2) Tor2-Mei2-Ste11 complex (IEA with S. pombe: tor2) cytosol (IEA with A. nidulans: torA, S. pombe: tor2) fungal-type vacuole (IEA with A. nidulans: torA) nuclear chromatin (IEA with S. pombe: tor2) perinuclear region of cytoplasm (IEA with S. pombe: tor2)

Mutant Phenotype		View all tor Phenotype details and references
Classical genetics
null		inviable
repressible		resistance to Congo Red: decreased resistance to caffeine: decreased resistance to sodium dodecyl sulfate: decreased

Sequence Information

Chr2_A_fumigatus_Af293:2631516 to 2624171 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2012-03-06 | Sequence: 2011-01-08

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-93	to	-1	2,631,609	to	2,631,517	2015-08-20	2015-08-20
CDS	1	to	127	2,631,516	to	2,631,390	2012-03-06	2011-01-08
Intron	128	to	192	2,631,389	to	2,631,325	2012-03-06	2011-01-08
CDS	193	to	1144	2,631,324	to	2,630,373	2012-03-06	2011-01-08
Intron	1145	to	1193	2,630,372	to	2,630,324	2012-03-06	2011-01-08
CDS	1194	to	6879	2,630,323	to	2,624,638	2012-03-06	2011-01-08
Intron	6880	to	6956	2,624,637	to	2,624,561	2012-03-06	2011-01-08
CDS	6957	to	7346	2,624,560	to	2,624,171	2012-03-06	2011-01-08

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

Sequence Variation

External Links

CADRE | FungiDB | GenBank (1, 2, 3, 4) | TrEMBL

Primary AspGDID

ASPL0000103742

ADDITIONAL INFORMATION for tor

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for tor

Name listed in the Broad Institute genome_summary_per_gene_file: phosphatidylinositol 3-kinase, putative

Last Updated: 2010-08-25

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for tor]

1)	*Baldin C, et al.* (2015)** Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13):2230-43
2)	AspGD (2012) Update of Aspergillus fumigatus Af293 reference annotation

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To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.