A. fumigatus vosA/Afu4g10860 Summary

Summary

Locus History

vosA BASIC INFORMATION [ View References ]

Standard Name

vosA¹

Systematic Name, Reference Strain

Afu4g10860 (A. fumigatus Af293)

Alias

AFUA_4G10860, CADAFUAG00007724²

Systematic Names Used in Other Strains

AFUB_067940 (A. fumigatus A1163)

Feature Type

ORF, Verified

Description

Velvet family protein; role in negative regulation of conidium formation and conidial germination; required for trehalose biosynthesis and H2O2 stress tolerance (3)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090005000209, AO090003001124
A. nidulans FGSC A4 Ortholog(s) : AN1959/vosA
View ortholog cluster : 21 genes among 19 Aspergillus-related species/strains
View alignment

Best hit(s) in non-AspGD species

N. crassa (NCU05964)

Best hits in Aspergillus species

A. niger CBS 513.88 best hit(s) : An04g05790

Chromosomal Location

GBrowse for A. fumigatus Af293
Click on map for expanded view
Afu4g10860

GO Annotations		View all vosA GO evidence and references
Molecular Function
Manually curated		molecular_function unknown (ND)
Biological Process
Manually curated		cellular response to UV (IMP) cellular response to hydrogen peroxide (IMP) conidiophore development (IMP) negative regulation of conidiophore development (IMP) negative regulation of sexual sporulation resulting in formation of a cellular spore (IMP) spore germination (IMP) sporulation resulting in formation of a cellular spore (IMP) trehalose biosynthetic process (IMP)
Computational		conidium formation (IEA with A. nidulans: vosA)
Cellular Component
Computational		nucleus (IEA with A. nidulans: vosA)

Mutant Phenotype		View all vosA Phenotype details and references
Classical genetics
null		UV resistance: decreased trehalose accumulation: decreased conidial germination: premature conidiation: increased resistance to hydrogen peroxide: decreased viable

Sequence Information

Chr4_A_fumigatus_Af293:2843361 to 2841372 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2012-03-06 | Sequence: 2011-01-07

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
CDS	1	to	187	2,843,361	to	2,843,175	2012-03-06	2011-01-07
Intron	188	to	276	2,843,174	to	2,843,086	2012-03-06	2011-01-07
CDS	277	to	346	2,843,085	to	2,843,016	2012-03-06	2011-01-07
Intron	347	to	450	2,843,015	to	2,842,912	2012-03-06	2011-01-07
CDS	451	to	557	2,842,911	to	2,842,805	2012-03-06	2011-01-07
Intron	558	to	615	2,842,804	to	2,842,747	2012-03-06	2011-01-07
CDS	616	to	700	2,842,746	to	2,842,662	2012-03-06	2011-01-07
Intron	701	to	770	2,842,661	to	2,842,592	2012-03-06	2011-01-07
CDS	771	to	817	2,842,591	to	2,842,545	2012-03-06	2011-01-07
Intron	818	to	873	2,842,544	to	2,842,489	2012-03-06	2011-01-07
CDS	874	to	985	2,842,488	to	2,842,377	2012-03-06	2011-01-07
Intron	986	to	1061	2,842,376	to	2,842,301	2012-03-06	2011-01-07
CDS	1062	to	1383	2,842,300	to	2,841,979	2012-03-06	2011-01-07
Intron	1384	to	1512	2,841,978	to	2,841,850	2012-03-06	2011-01-07
CDS	1513	to	1635	2,841,849	to	2,841,727	2012-03-06	2011-01-07
Intron	1636	to	1705	2,841,726	to	2,841,657	2012-03-06	2011-01-07
CDS	1706	to	1990	2,841,656	to	2,841,372	2012-03-06	2011-01-07

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

Sequence Variation

External Links

CADRE | FungiDB | GenBank (1, 2, 3, 4) | TrEMBL

Primary AspGDID

ASPL0000106799

ADDITIONAL INFORMATION for vosA

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for vosA

Name listed in the Broad Institute genome_summary_per_gene_file: hypothetical protein

Last Updated: 2010-08-25

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for vosA]

1)	*Kwon NJ, et al.* (2010)** Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans. Fungal Genet Biol 47(12):981-93
2)	AspGD (2012) Update of Aspergillus fumigatus Af293 reference annotation
3)	*Park HS, et al.* (2012)** Characterization of the velvet regulators in Aspergillus fumigatus. Mol Microbiol 86(4):937-53

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To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.