A. fumigatus hapX/Afu5g03920 Summary

Summary

Locus History

hapX BASIC INFORMATION [ View References ]

Standard Name

hapX¹

Systematic Name, Reference Strain

Afu5g03920 (A. fumigatus Af293)

Alias

AFUA_5G03920, CADAFUAG00002933²

Systematic Names Used in Other Strains

AFUB_052420 (A. fumigatus A1163)

Feature Type

ORF, Verified

Description

bZIP transcription factor required for adaption to both iron depletion and excess and for transcriptional activation of the siderophore system; transcript repressed by iron; SrbA-regulated during hypoxia (1, 3, 4, 5)

Literature

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090102000597
A. nidulans FGSC A4 Ortholog(s) : AN8251/hapX
A. niger CBS 513.88 Ortholog(s) : An09g06280
View ortholog cluster : 20 genes among 20 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (NCU08891) ; C. albicans (HAP43)

Chromosomal Location

GBrowse for A. fumigatus Af293
Click on map for expanded view
Afu5g03920

GO Annotations		View all hapX GO evidence and references
Molecular Function
Computational		sequence-specific DNA binding (IEA with EBI: IPR004827) transcription coactivator activity (IEA with C. albicans: HAP43) transcription factor activity, sequence-specific DNA binding (IEA with EBI: IPR004827) transcription regulatory region DNA binding (IEA with C. albicans: HAP43)
Biological Process
Manually curated		N',N'',N'''-triacetylfusarinine C biosynthetic process (IMP) cellular response to iron ion starvation (IMP) ferricrocin biosynthetic process (IMP) pathogenesis (IMP)
Computational		cellular response to alkaline pH (IEA with C. albicans: HAP43) iron assimilation (IEA with C. albicans: HAP43) negative regulation of iron ion transport (IEA with A. nidulans: hapX) negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation (IEA with C. albicans: HAP43)
Cellular Component
Computational		CCAAT-binding factor complex (IEA with C. albicans: HAP43, A. nidulans: hapX)

Mutant Phenotype		View all hapX Phenotype details and references
Classical genetics
null		sidG mRNA accumulation: decreased protoporphyrin IX accumulation: increased conidiation: decreased resistance to bathophenanthroline disulfonate: decreased resistance to zinc: decreased ferricrocin production: decreased triacetylfusarinine C production: decreased viable virulence: decreased virulence: normal

Sequence Information

Chr5_A_fumigatus_Af293:1044453 to 1042978 | GBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2011-01-07 | Sequence: 2011-01-07

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
5' UTR	-810	to	-130	1,045,263	to	1,044,583	2015-08-20	2015-08-20
5' UTR intron	-129	to	-42	1,044,582	to	1,044,495	2013-03-13	2013-03-13
5' UTR	-41	to	-1	1,044,494	to	1,044,454	2013-03-13	2013-03-13
CDS	1	to	1476	1,044,453	to	1,042,978	2011-01-07	2011-01-07

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays

RNA-Seq Data

Sequence Variation

External Links

CADRE | FungiDB | GenBank (1, 2, 3, 4) | TrEMBL

Primary AspGDID

ASPL0000107570

ADDITIONAL INFORMATION for hapX

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for hapX

Name listed in the Broad Institute genome_summary_per_gene_file: bZIP transcription factor (HapX), putative

Last Updated: 2010-08-25

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for hapX]

1)	*Schrettl M, et al.* (2008)** SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1):27-43
2)	AspGD (2012) Update of Aspergillus fumigatus Af293 reference annotation
3)	*Schrettl M, et al.* (2010)** HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6(9):e1001124
4)	*Blatzer M, et al.* (2011)** SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374
5)	*Gsaller F, et al.* (2014)** The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76

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To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.