A. niger An02g07430 Summary

Summary

Locus History

An02g07430 BASIC INFORMATION [ View References ]

Systematic Name, Reference Strain

An02g07430 (A. niger CBS 513.88)

Systematic Names Used in Other Strains

52305-mRNA (A. niger ATCC 1015)

Feature Type

ORF, Verified

Description

Homoserine dehydrogenase (1, 2)

Orthologous genes in Aspergillus species

A. oryzae RIB40 Ortholog(s) : AO090003000721, AO090009000136
A. fumigatus Af293 Ortholog(s) : Afu3g11640
A. nidulans FGSC A4 Ortholog(s) : AN2882
View ortholog cluster : 24 genes among 21 Aspergillus-related species/strains
View alignment

Ortholog(s) in non-AspGD species

N. crassa (NCU03935) ; C. albicans (HOM6) ; S. pombe (SPBC776.03) ; S. cerevisiae (HOM6)

Chromosomal Location

GBrowse for A. niger CBS 513.88
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An02g07430

GO Annotations		View all An02g07430 GO evidence and references
Molecular Function
Computational		NADP binding (IEA with EBI: IPR005106) homoserine dehydrogenase activity (IEA with S. cerevisiae: HOM6)
Biological Process
Computational		homoserine biosynthetic process (IEA with S. cerevisiae: HOM6, C. albicans: HOM6) methionine biosynthetic process (IEA with S. cerevisiae: HOM6, C. albicans: HOM6) oxidation-reduction process (IEA with EBI: IPR001342, EBI: IPR005106) threonine biosynthetic process (IEA with S. cerevisiae: HOM6, C. albicans: HOM6)
Cellular Component
Manually curated		intracellular (IDA)
Computational		cytoplasm (IEA with S. cerevisiae: HOM6) nucleus (IEA with S. cerevisiae: HOM6)

Sequence Information

An02_A_niger_CBS_513_88:1774610 to 1775842 | GBrowse

Last Update

Coordinates: 2011-08-18 | Sequence: 2011-08-18

Subfeature Details

	Relative Coordinates			Chromosomal Coordinates			Most Recent Update
	Relative Coordinates			Chromosomal Coordinates			Coordinates	Sequence
CDS	1	to	31	1,774,610	to	1,774,640	2011-08-18	2011-08-18
Intron	32	to	151	1,774,641	to	1,774,760	2011-08-18	2011-08-18
CDS	152	to	1233	1,774,761	to	1,775,842	2011-08-18	2011-08-18

Retrieve Sequences
Sequence Analysis Tools
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RNA-Seq Data

External Links

FungiDB | GenBank (1, 2) | TrEMBL

Primary AspGDID

ASPL0000216532

ADDITIONAL INFORMATION for An02g07430

Locus History

Gene/Sequence Resources

LOCUS SUMMARY NOTES for An02g07430

Information from the GenBank record :

db_xref = GI:134056799, GOA:A2QDK6
inference = profile:COGS:COG0460, profile:PFAM:PF00742, similar to AA sequence:PIR:S33317
protein_id = CAK37707.1
EC_number = 1.1.1.3
note = unnamed protein product; Function: homoserine dehydrogenases catalyze the NAD-dependent reduction of aspartate beta-semialdehyde into homoserine, which participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine.; Remark: the yeast enzyme acts most rapidly with NAD(+); Neurospora enzyme with NADP(+). Enzyme from E. coli is a multifunctional protein, which also acts as aspartate kinase (EC 2. 7. 2. 4).; Title: strong similarity to homoserine dehydrogenase YJR139c - Saccharomyces cerevisiae

Last Updated: 2011-08-19

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for An02g07430]

1)	*Lu X, et al.* (2010)** The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate. Microb Cell Fact 9:23
2)	*Andersen MR, et al.* (2008)** Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. Mol Syst Biol 4:178

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