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4 Single Mutant Phenotype(s) for anaerobic growth
Gene Name Organism Experiment type Mutant Information Phenotype Details Virulence Model References All phenotypes
facA/AN5626 A. nidulans classical genetics Description: unspecified
Allele: facA303 		anaerobic growth: decreased Details: decreased anaerobic cell growth during ammonia fermentation
Takasaki K, et al.  (2004) Fungal ammonia fermentation, a novel metabolic mechanism that couples the dissimilatory and assimilatory pathways of both nitrate and ethanol. Role of acetyl CoA synthetase in anaerobic ATP synthesis. J Biol Chem 279(13):12414-20
facA phenotypes
ireA/Afu1g01720 A. fumigatus classical genetics Description: null anaerobic growth: decreased immunosuppressed mouse pulmonary infection
Feng X, et al.  (2011) HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 7(10):e1002330
ireA phenotypes
srbA/Afu2g01260 A. fumigatus classical genetics Description: null anaerobic growth: absent Details: mutants are unable to grow under hypoxic conditions
Blatzer M, et al.  (2011) SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374
srbA phenotypes
srbA/Afu2g01260 A. fumigatus classical genetics Description: null anaerobic growth: absent Willger SD, et al.  (2008) A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog 4(11):e1000200
srbA phenotypes


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Curation of mutant phenotypes is an ongoing project at AspGD. Please contact AspGD curators to let us know of additional phenotype information that should be incorporated.


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