| Author(s) | Citation |
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| Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM | Marion A, et al. (2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol
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| Valiante V, Baldin C, Hortschansky P, Jain R, Thywissen A, Strassburger M, Shelest E, Heinekamp T, Brakhage AA | Valiante V, et al. (2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol 102(2):321-335
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| Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N | Vaknin Y, et al. (2016) Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence. Infect Immun 84(6):1866-78
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| Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Loffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O | Teutschbein J, et al. (2016) Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis. J Proteome Res 15(5):1580-91
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| Johnk B, Bayram O, Abelmann A, Heinekamp T, Mattern DJ, Brakhage AA, Jacobsen ID, Valerius O, Braus GH | Johnk B, et al. (2016) SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus. PLoS Pathog 12(9):e1005899
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| Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Muller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ | Gsaller F, et al. (2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog 12(7):e1005775
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| de Oliveira Bruder Nascimento AC, Dos Reis TF, de Castro PA, Hori JI, Bom VL, de Assis LJ, Ramalho LN, Rocha MC, Malavazi I, Brown NA, Valiante V, Brakhage AA, Hagiwara D, Goldman GH | Bruder Nascimento AC, et al. (2016) Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Mol Microbiol 100(5):841-59
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| Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA | Hortschansky P, et al. (2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10):6058-70
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| Gallmetzer A, Silvestrini L, Schinko T, Gesslbauer B, Hortschansky P, Dattenbock C, Muro-Pastor MI, Kungl A, Brakhage AA, Scazzocchio C, Strauss J | Gallmetzer A, et al. (2015) Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLoS Genet 11(7):e1005297
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| Baldin C, Valiante V, Kruger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA | Baldin C, et al. (2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13):2230-43
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| Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM | Scharf DH, et al. (2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8):2221-4
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| Kroll K, Pahtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O | Kroll K, et al. (2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival. Eukaryot Cell 13(9):1241-53
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| Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H | Gsaller F, et al. (2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76
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| Amin S, Thywissen A, Heinekamp T, Saluz HP, Brakhage AA | Amin S, et al. (2014) Melanin dependent survival of Apergillus fumigatus conidia in lung epithelial cells. Int J Med Microbiol 304(5-6):626-36
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| Shopova I, Bruns S, Thywissen A, Kniemeyer O, Brakhage AA, Hillmann F | Shopova I, et al. (2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4:141
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| Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C | Scharf DH, et al. (2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42):11092-5
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| Nutzmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA | Nutzmann HW, et al. (2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19):6102-9
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| Muszkieta L, Beauvais A, Pahtz V, Gibbons JG, Anton Leberre V, Beau R, Shibuya K, Rokas A, Francois JM, Kniemeyer O, Brakhage AA, Latge JP | Muszkieta L, et al. (2013) Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches. Front Microbiol 4:13
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| Konig CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C | Konig CC, et al. (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8):938-42
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| Beauvais A, Bozza S, Kniemeyer O, Formosa C, Balloy V, Henry C, Roberson RW, Dague E, Chignard M, Brakhage AA, Romani L, Latge JP | Beauvais A, et al. (2013) Deletion of the alpha-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus. PLoS Pathog 9(11):e1003716
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| Wartenberg D, Vodisch M, Kniemeyer O, Albrecht-Eckardt D, Scherlach K, Winkler R, Weide M, Brakhage AA | Wartenberg D, et al. (2012) Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. J Proteomics 75(13):4038-49
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| Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C | Scharf DH, et al. (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40):10064-8
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| Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C | Scharf DH, et al. (2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2):467-72
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| Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U | Sarkar A, et al. (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2):64-71
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| Muller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V | Muller S, et al. (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC Genomics 13:519
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| Monteiro MC, de la Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E, De Lucas JR, Asensio F, Valiante V, Brakhage AA, Latge JP, Genilloud O, Vicente F | Monteiro MC, et al. (2012) A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin. J Biomol Screen 17(4):542-9
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| Linde J, Hortschansky P, Fazius E, Brakhage AA, Guthke R, Haas H | Linde J, et al. (2012) Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6:6
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| Huber EM, Scharf DH, Hortschansky P, Groll M, Brakhage AA | Huber EM, et al. (2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10):1757-68
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| Horn F, Heinekamp T, Kniemeyer O, Pollmacher J, Valiante V, Brakhage AA | Horn F, et al. (2012) Systems biology of fungal infection. Front Microbiol 3:108
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| Heinekamp T, Thywissen A, Macheleidt J, Keller S, Valiante V, Brakhage AA | Heinekamp T, et al. (2012) Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol 3:440
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| Gil Girol C, Fisch KM, Heinekamp T, Gunther S, Huttel W, Piel J, Brakhage AA, Muller M | Gil Girol C, et al. (2012) Regio- and stereoselective oxidative phenol coupling in Aspergillus niger. Angew Chem Int Ed Engl 51(39):9788-91
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| Wartenberg D, Lapp K, Jacobsen ID, Dahse HM, Kniemeyer O, Heinekamp T, Brakhage AA | Wartenberg D, et al. (2011) Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol 301(7):602-11
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| Volling K, Thywissen A, Saluz HP, Brakhage AA | Volling K, et al. (2011) Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8):1130-48
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| Vodisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O | Vodisch M, et al. (2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5):2508-24
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| Thywissen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA | Thywissen A, et al. (2011) Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway. Front Microbiol 2:96
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| Scherlach K, Nutzmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C | Scherlach K, et al. (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42):9843-7
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| Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C | Scharf DH, et al. (2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32):12322-5
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| Priebe S, Linde J, Albrecht D, Guthke R, Brakhage AA | Priebe S, et al. (2011) FungiFun: a web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol 48(4):353-8
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| Nutzmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schumann J, Hertweck C, Strauss J, Brakhage AA | Nutzmann HW, et al. (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34):14282-7
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| Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT | Mech F, et al. (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One 6(5):e19591
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| Kniemeyer O, Schmidt AD, Vodisch M, Wartenberg D, Brakhage AA | Kniemeyer O, et al. (2011) Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics. Int J Med Microbiol 301(5):368-77
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| Keller S, Macheleidt J, Scherlach K, Schmaler-Ripcke J, Jacobsen ID, Heinekamp T, Brakhage AA | Keller S, et al. (2011) Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence. PLoS One 6(10):e26604
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| Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA | Jain R, et al. (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1):39-53
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| Hasenberg M, Behnsen J, Krappmann S, Brakhage A, Gunzer M | Hasenberg M, et al. (2011) Phagocyte responses towards Aspergillus fumigatus. Int J Med Microbiol 301(5):436-44
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| Brakhage AA, Schroeckh V | Brakhage AA and Schroeckh V (2011) Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol 48(1):15-22
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| Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R | Albrecht D, et al. (2011) On the way toward systems biology of Aspergillus fumigatus infection. Int J Med Microbiol 301(5):453-9
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| Thon M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA | Thon M, et al. (2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4):1098-113
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| Teutschbein J, Albrecht D, Potsch M, Guthke R, Aimanianda V, Clavaud C, Latge JP, Brakhage AA, Kniemeyer O | Teutschbein J, et al. (2010) Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res 9(7):3427-42
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| Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jochl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H | Schrettl M, et al. (2010) HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6(9):e1001124
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| Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C | Scharf DH, et al. (2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29):10136-41
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| Mouyna I, Kniemeyer O, Jank T, Loussert C, Mellado E, Aimanianda V, Beauvais A, Wartenberg D, Sarfati J, Bayry J, Prevost MC, Brakhage AA, Strahl S, Huerre M, Latge JP | Mouyna I, et al. (2010) Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability. Mol Microbiol 76(5):1205-21
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| Gehrke A, Heinekamp T, Jacobsen ID, Brakhage AA | Gehrke A, et al. (2010) Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence. Appl Environ Microbiol 76(12):3989-98
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| Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywissen A, Jeron A, Latge JP, Brakhage AA, Gunzer M | Bruns S, et al. (2010) Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog 6(4):e1000873
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| Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Muller FM | Bruns S, et al. (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17):3097-107
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| Brakhage AA, Bruns S, Thywissen A, Zipfel PF, Behnsen J | Brakhage AA, et al. (2010) Interaction of phagocytes with filamentous fungi. Curr Opin Microbiol 13(4):409-15
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| Bergmann S, Funk AN, Scherlach K, Schroeckh V, Shelest E, Horn U, Hertweck C, Brakhage AA | Bergmann S, et al. (2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24):8143-9
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| Behnsen J, Lessing F, Schindler S, Wartenberg D, Jacobsen ID, Thoen M, Zipfel PF, Brakhage AA | Behnsen J, et al. (2010) Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun 78(8):3585-94
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| Albrecht D, Guthke R, Brakhage AA, Kniemeyer O | Albrecht D, et al. (2010) Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics 11:32
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| Vodisch M, Albrecht D, Lessing F, Schmidt AD, Winkler R, Guthke R, Brakhage AA, Kniemeyer O | Vodisch M, et al. (2009) Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics 9(5):1407-15
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| Valiante V, Jain R, Heinekamp T, Brakhage AA | Valiante V, et al. (2009) The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet Biol 46(12):909-18
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| Sprote P, Brakhage AA, Hynes MJ | Sprote P, et al. (2009) Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans. Eukaryot Cell 8(3):421-3
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| Schroeckh V, Scherlach K, Nutzmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA | Schroeckh V, et al. (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34):14558-63
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| Schmaler-Ripcke J, Sugareva V, Gebhardt P, Winkler R, Kniemeyer O, Heinekamp T, Brakhage AA | Schmaler-Ripcke J, et al. (2009) Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol 75(2):493-503
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| Kniemeyer O, Lessing F, Brakhage AA | Kniemeyer O, et al. (2009) Proteome analysis for pathogenicity and new diagnostic markers for Aspergillus fumigatus. Med Mycol 47 Suppl 1:S248-54
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| Brakhage AA, Thon M, Sprote P, Scharf DH, Al-Abdallah Q, Wolke SM, Hortschansky P | Brakhage AA, et al. (2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70(15-16):1801-11
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| Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, Elluru SR, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latge JP | Aimanianda V, et al. (2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460(7259):1117-21
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| Valiante V, Heinekamp T, Jain R, Hartl A, Brakhage AA | Valiante V, et al. (2008) The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal Genet Biol 45(5):618-27
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| Sprote P, Hynes MJ, Hortschansky P, Shelest E, Scharf DH, Wolke SM, Brakhage AA | Sprote P, et al. (2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70(2):445-61
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| Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H | Schrettl M, et al. (2008) SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1):27-43
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| Mota Junior AO, Malavazi I, Soriani FM, Heinekamp T, Jacobsen I, Brakhage AA, Savoldi M, Goldman MH, da Silva Ferreira ME, Goldman GH | Mota Junior AO, et al. (2008) Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA. Mol Genet Genomics 280(6):483-95
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| Ibrahim-Granet O, Dubourdeau M, Latge JP, Ave P, Huerre M, Brakhage AA, Brock M | Ibrahim-Granet O, et al. (2008) Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol 10(1):134-48
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| Grosse C, Heinekamp T, Kniemeyer O, Gehrke A, Brakhage AA | Grosse C, et al. (2008) Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus. Appl Environ Microbiol 74(15):4923-33
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| Behnsen J, Hartmann A, Schmaler J, Gehrke A, Brakhage AA, Zipfel PF | Behnsen J, et al. (2008) The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system. Infect Immun 76(2):820-7
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| da Silva Ferreira ME, Heinekamp T, Hartl A, Brakhage AA, Semighini CP, Harris SD, Savoldi M, de Gouvea PF, de Souza Goldman MH, Goldman GH | da Silva Ferreira ME, et al. (2007) Functional characterization of the Aspergillus fumigatus calcineurin. Fungal Genet Biol 44(3):219-30
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| Volling K, Brakhage AA, Saluz HP | Volling K, et al. (2007) Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2):250-4
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| Thon M, Al-Abdallah Q, Hortschansky P, Brakhage AA | Thon M, et al. (2007) The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response. J Biol Chem 282(37):27259-69
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| Sprote P, Brakhage AA | Sprote P and Brakhage AA (2007) The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis. Arch Microbiol 188(1):69-79
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| Schobel F, Ibrahim-Granet O, Ave P, Latge JP, Brakhage AA, Brock M | Schobel F, et al. (2007) Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. Infect Immun 75(3):1237-44
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| Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F | Luther K, et al. (2007) Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 9(2):368-81
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| Lessing F, Kniemeyer O, Wozniok I, Loeffler J, Kurzai O, Haertl A, Brakhage AA | Lessing F, et al. (2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12):2290-302
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| Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thon M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H | Hortschansky P, et al. (2007) Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13):3157-68
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| Bergmann S, Schumann J, Scherlach K, Lange C, Brakhage AA, Hertweck C | Bergmann S, et al. (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4):213-7
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| Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M | Behnsen J, et al. (2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 3(2):e13
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| da Silva Ferreira ME, Malavazi I, Savoldi M, Brakhage AA, Goldman MH, Kim HS, Nierman WC, Goldman GH | da Silva Ferreira ME, et al. (2006) Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Curr Genet 50(1):32-44
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| da Silva Ferreira ME, Kress MR, Savoldi M, Goldman MH, Hartl A, Heinekamp T, Brakhage AA, Goldman GH | da Silva Ferreira ME, et al. (2006) The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5(1):207-11
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| Sugareva V, Hartl A, Brock M, Hubner K, Rohde M, Heinekamp T, Brakhage AA | Sugareva V, et al. (2006) Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus. Arch Microbiol 186(5):345-55
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| Kupfahl C, Heinekamp T, Geginat G, Ruppert T, Hartl A, Hof H, Brakhage AA | Kupfahl C, et al. (2006) Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol 62(1):292-302
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| Kniemeyer O, Lessing F, Scheibner O, Hertweck C, Brakhage AA | Kniemeyer O, et al. (2006) Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet 49(3):178-89
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| Herrmann M, Sprote P, Brakhage AA | Herrmann M, et al. (2006) Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. Appl Environ Microbiol 72(4):2957-70
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| Ebel F, Schwienbacher M, Beyer J, Heesemann J, Brakhage AA, Brock M | Ebel F, et al. (2006) Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development. Fungal Genet Biol 43(7):476-89
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| Tuncher A, Sprote P, Gehrke A, Brakhage AA | Tuncher A, et al. (2005) The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human. J Mol Biol 352(3):517-33
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| Maerker C, Rohde M, Brakhage AA, Brock M | Maerker C, et al. (2005) Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J 272(14):3615-30
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| Goda H, Nagase T, Tanoue S, Sugiyama J, Steidl S, Tuncher A, Kobayashi T, Tsukagoshi N, Brakhage AA, Kato M | Goda H, et al. (2005) Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunit. Arch Microbiol 184(2):93-100
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| Brakhage AA, Liebmann B | Brakhage AA and Liebmann B (2005) Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulence. Med Mycol 43 Suppl 1:S75-82
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| Brakhage AA | Brakhage AA (2005) Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants. Curr Drug Targets 6(8):875-86
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| Tuncher A, Reinke H, Martic G, Caruso ML, Brakhage AA | Tuncher A, et al. (2004) A basic-region helix-loop-helix protein-encoding gene (devR) involved in the development of Aspergillus nidulans. Mol Microbiol 52(1):227-41
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| Steidl S, Tuncher A, Goda H, Guder C, Papadopoulou N, Kobayashi T, Tsukagoshi N, Kato M, Brakhage AA | Steidl S, et al. (2004) A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus. J Mol Biol 342(2):515-24
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| Liebmann B, Muller M, Braun A, Brakhage AA | Liebmann B, et al. (2004) The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus. Infect Immun 72(9):5193-203
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| Liebmann B, Muhleisen TW, Muller M, Hecht M, Weidner G, Braun A, Brock M, Brakhage AA | Liebmann B, et al. (2004) Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis. Arch Microbiol 181(5):378-83
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| Brakhage AA, Sprote P, Al-Abdallah Q, Gehrke A, Plattner H, Tuncher A | Brakhage AA, et al. (2004) Regulation of penicillin biosynthesis in filamentous fungi. Adv Biochem Eng Biotechnol 88:45-90
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| Liebmann B, Gattung S, Jahn B, Brakhage AA | Liebmann B, et al. (2003) cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages. Mol Genet Genomics 269(3):420-35
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| Langfelder K, Streibel M, Jahn B, Haase G, Brakhage AA | Langfelder K, et al. (2003) Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Fungal Genet Biol 38(2):143-58
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| Busch S, Bode HB, Brakhage AA, Braus GH | Busch S, et al. (2003) Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans. Curr Genet 42(4):209-19
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| Langfelder K, Gattung S, Brakhage AA | Langfelder K, et al. (2002) A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene. Curr Genet 41(4):268-74
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| Jahn B, Langfelder K, Schneider U, Schindel C, Brakhage AA | Jahn B, et al. (2002) PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages. Cell Microbiol 4(12):793-803
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| Caruso ML, Litzka O, Martic G, Lottspeich F, Brakhage AA | Caruso ML, et al. (2002) Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene. J Mol Biol 323(3):425-39
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| Brakhage AA, Langfelder K | Brakhage AA and Langfelder K (2002) Menacing mold: the molecular biology of Aspergillus fumigatus. Annu Rev Microbiol 56:433-55
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| Weidner G, Steidl S, Brakhage AA | Weidner G, et al. (2001) The Aspergillus nidulans homoaconitase gene lysF is negatively regulated by the multimeric CCAAT-binding complex AnCF and positively regulated by GATA sites. Arch Microbiol 175(2):122-32
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| Tanaka A, Kamei K, Tanoue S, Papagiannopoulos P, Steidl S, Brakhage AA, Davis MA, Hynes MJ, Kato M, Kobayashi T, Tsukagoshi N | Tanaka A, et al. (2001) AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the corresponding subunits in Aspergillus nidulans. Curr Genet 39(3):175-82
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| Steidl S, Hynes MJ, Brakhage AA | Steidl S, et al. (2001) The Aspergillus nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene. J Mol Biol 306(4):643-53
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| Langfelder K, Philippe B, Jahn B, Latge JP, Brakhage AA | Langfelder K, et al. (2001) Differential expression of the Aspergillus fumigatus pksP gene detected in vitro and in vivo with green fluorescent protein. Infect Immun 69(10):6411-8
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| Jahn B, Boukhallouk F, Lotz J, Langfelder K, Wanner G, Brakhage AA | Jahn B, et al. (2000) Interaction of human phagocytes with pigmentless Aspergillus conidia. Infect Immun 68(6):3736-9
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| D'Enfert C, Weidner G, Mol PC, Brakhage AA | d'Enfert C, et al. (1999) Transformation systems of Aspergillus fumigatus. New tools to investigate fungal virulence. Contrib Microbiol 2:149-66
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| Van Den Brulle J, Steidl S, Brakhage AA | Van Den Brulle J, et al. (1999) Cloning and characterization of an Aspergillus nidulans gene involved in the regulation of penicillin biosynthesis. Appl Environ Microbiol 65(12):5222-8
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| Steidl S, Papagiannopoulos P, Litzka O, Andrianopoulos A, Davis MA, Brakhage AA, Hynes MJ | Steidl S, et al. (1999) AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR. Mol Cell Biol 19(1):99-106
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| Litzka O, Then Bergh K, Van den Brulle J, Steidl S, Brakhage AA | Litzka O, et al. (1999) Transcriptional control of expression of fungal beta-lactam biosynthesis genes. Antonie Van Leeuwenhoek 75(1-2):95-105
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| Brakhage AA, Langfelder K, Wanner G, Schmidt A, Jahn B | Brakhage AA, et al. (1999) Pigment biosynthesis and virulence. Contrib Microbiol 2:205-15
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| Brakhage AA, Andrianopoulos A, Kato M, Steidl S, Davis MA, Tsukagoshi N, Hynes MJ | Brakhage AA, et al. (1999) HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology. Fungal Genet Biol 27(2-3):243-52
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| Weidner G, d'Enfert C, D'Enfert C, Koch A, Mol PC, Brakhage AA | Weidner G, et al. (1998) Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5'-monophosphate decarboxylase. Curr Genet 33(5):378-85
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| Then Bergh K, Brakhage AA | Then Bergh K and Brakhage AA (1998) Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC. Appl Environ Microbiol 64(3):843-9
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| Litzka O, Papagiannopolous P, Davis MA, Hynes MJ, Brakhage AA | Litzka O, et al. (1998) The penicillin regulator PENR1 of Aspergillus nidulans is a HAP-like transcriptional complex. Eur J Biochem 251(3):758-67
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| Langfelder K, Jahn B, Gehringer H, Schmidt A, Wanner G, Brakhage AA | Langfelder K, et al. (1998) Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol 187(2):79-89
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| Brakhage AA | Brakhage AA (1998) Molecular regulation of beta-lactam biosynthesis in filamentous fungi. Microbiol Mol Biol Rev 62(3):547-85
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| Weidner G, Steffan B, Brakhage AA | Weidner G, et al. (1997) The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway. Mol Gen Genet 255(3):237-47
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| Jahn B, Koch A, Schmidt A, Wanner G, Gehringer H, Bhakdi S, Brakhage AA | Jahn B, et al. (1997) Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect Immun 65(12):5110-7
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| Brakhage AA | Brakhage AA (1997) Molecular regulation of penicillin biosynthesis in Aspergillus (Emericella) nidulans. FEMS Microbiol Lett 148(1):1-10
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| Litzka O, Then Bergh K, Brakhage AA | Litzka O, et al. (1996) The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element. Eur J Biochem 238(3):675-82
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| Bergh KT, Litzka O, Brakhage AA | Bergh KT, et al. (1996) Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans. J Bacteriol 178(13):3908-16
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| Litzka O, Bergh KT, Brakhage AA | Litzka O, et al. (1995) Analysis of the regulation of the Aspergillus nidulans penicillin biosynthesis gene aat (penDE), which encodes acyl coenzyme A:6-aminopenicillanic acid acyltransferase. Mol Gen Genet 249(5):557-69
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| Brakhage AA, Van den Brulle J | Brakhage AA and Van den Brulle J (1995) Use of reporter genes to identify recessive trans-acting mutations specifically involved in the regulation of Aspergillus nidulans penicillin biosynthesis genes. J Bacteriol 177(10):2781-8
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| Brakhage AA, Browne P, Turner G | Brakhage AA, et al. (1994) Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted disruption of the acvA gene. Mol Gen Genet 242(1):57-64
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| Brakhage AA, Browne P, Turner G | Brakhage AA, et al. (1992) Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose. J Bacteriol 174(11):3789-99
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| Brakhage AA, Turner G | Brakhage AA and Turner G (1992) L-lysine repression of penicillin biosynthesis and the expression of penicillin biosynthesis genes acvA and ipnA in Aspergillus nidulans. FEMS Microbiol Lett 77(1-3):123-7
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