AspGD Curated Papers

Author(s)	Citation
Thammahong A, Caffrey-Card AK, Dhingra S, Obar JJ, Cramer RA	*Thammahong A, et al.* (2017)** Aspergillus fumigatus Trehalose-Regulatory Subunit Homolog Moonlights To Mediate Cell Wall Homeostasis through Modulation of Chitin Synthase Activity. MBio 8(2)
Dhingra S, Cramer RA	Dhingra S and Cramer RA (2017) Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol 8:92
Ries LN, Beattie SR, Espeso EA, Cramer RA, Goldman GH	*Ries LN, et al.* (2016)** Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics 203(1):335-52
Fuller KK, Cramer RA, Zegans ME, Dunlap JC, Loros JJ	*Fuller KK, et al.* (2016)** Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates. MBio 7(5)
Dhingra S, Kowlaski CH, Thammahong A, Beattie SR, Bultman KM, Cramer RA	*Dhingra S, et al.* (2016)** RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus. mSphere 1(2)
Lima Pde S, Chung D, Bailao AM, Cramer RA, Soares CM	*Lima Pde S, et al.* (2015)** Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus. PLoS Negl Trop Dis 9(12):e0004282
Losada L, Barker BM, Pakala S, Pakala S, Joardar V, Zafar N, Mounaud S, Fedorova N, Nierman WC, Cramer RA	*Losada L, et al.* (2014)** Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA. Mycopathologia 178(5-6):331-9
Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H	*Gsaller F, et al.* (2014)** The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76
Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA	*Chung D, et al.* (2014)** ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog 10(11):e1004487
Blosser SJ, Merriman B, Grahl N, Chung D, Cramer RA	*Blosser SJ, et al.* (2014)** Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. Microbiology 160(Pt 11):2492-506
Shepardson KM, Ngo LY, Aimanianda V, Latge JP, Barker BM, Blosser SJ, Iwakura Y, Hohl TM, Cramer RA	*Shepardson KM, et al.* (2013)** Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbes Infect 15(4):259-69
Willger SD, Cornish EJ, Chung D, Fleming BA, Lehmann MM, Puttikamonkul S, Cramer RA	*Willger SD, et al.* (2012)** Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus. Eukaryot Cell 11(12):1557-67
Grahl N, Shepardson KM, Chung D, Cramer RA	*Grahl N, et al.* (2012)** Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell 11(5):560-70
Grahl N, Dinamarco TM, Willger SD, Goldman GH, Cramer RA	*Grahl N, et al.* (2012)** Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis. Mol Microbiol 84(2):383-99
Blosser SJ, Cramer RA	Blosser SJ and Cramer RA (2012) SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). Antimicrob Agents Chemother 56(1):248-57
Barker BM, Kroll K, Vodisch M, Mazurie A, Kniemeyer O, Cramer RA	*Barker BM, et al.* (2012)** Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. BMC Genomics 13:62
Wezensky SJ, Cramer RA	Wezensky SJ and Cramer RA Jr (2011) Implications of hypoxic microenvironments during invasive aspergillosis. Med Mycol 49 Suppl 1:S120-4
Li H, Barker B, Grahl N, Puttikamonkul S, Bell JD, Craven KD, Cramer RA Jr	*Li H, et al.* (2011)** The small GTPase RacA mediates intracellular reactive oxygen species production, polarized growth, and virulence in the human fungal pathogen Aspergillus fumigatus. Eukaryot Cell 10(2):174-86
Grahl N, Puttikamonkul S, Macdonald JM, Gamcsik MP, Ngo LY, Hohl TM, Cramer RA	*Grahl N, et al.* (2011)** In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog 7(7):e1002145
Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latge JP, Woollett L, Newman SL, Cramer RA Jr, Rhodes JC, Askew DS	*Feng X, et al.* (2011)** HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 7(10):e1002330
Cramer RA, Rivera A, Hohl TM	*Cramer RA, et al.* (2011)** Immune responses against Aspergillus fumigatus: what have we learned? Curr Opin Infect Dis 24(4):315-22
Blatzer M, Barker BM, Willger SD, Beckmann N, Blosser SJ, Cornish EJ, Mazurie A, Grahl N, Haas H, Cramer RA	*Blatzer M, et al.* (2011)** SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374
Willger SD, Grahl N, Cramer RA Jr	*Willger SD, et al.* (2009)** Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol 47 Suppl 1:S72-9
Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA Jr, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ	*Pinchai N, et al.* (2009)** Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell 8(4):511-9
Kim KH, Willger SD, Park SW, Puttikamonkul S, Grahl N, Cho Y, Mukhopadhyay B, Cramer RA Jr, Lawrence CB	*Kim KH, et al.* (2009)** TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen. PLoS Pathog 5(11):e1000653
Willger SD, Puttikamonkul S, Kim KH, Burritt JB, Grahl N, Metzler LJ, Barbuch R, Bard M, Lawrence CB, Cramer RA Jr	*Willger SD, et al.* (2008)** A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog 4(11):e1000200
Cramer RA Jr, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ	*Cramer RA Jr, et al.* (2008)** Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell 7(7):1085-97
Steinbach WJ, Reedy JL, Cramer RA Jr, Perfect JR, Heitman J	*Steinbach WJ, et al.* (2007)** Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol 5(6):418-30
Steinbach WJ, Cramer RA Jr, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR	*Steinbach WJ, et al.* (2007)** Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother 51(8):2979-81
Perrin RM, Fedorova ND, Bok JW, Cramer RA, Wortman JR, Kim HS, Nierman WC, Keller NP	*Perrin RM, et al.* (2007)** Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathog 3(4):e50
Steinbach WJ, Cramer RA Jr, Perfect BZ, Asfaw YG, Sauer TC, Najvar LK, Kirkpatrick WR, Patterson TF, Benjamin DK Jr, Heitman J, Perfect JR	*Steinbach WJ, et al.* (2006)** Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5(7):1091-103
Cramer RA Jr, Stajich JE, Yamanaka Y, Dietrich FS, Steinbach WJ, Perfect JR	*Cramer RA Jr, et al.* (2006)** Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. Gene 383:24-32
Cramer RA Jr, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ	*Cramer RA Jr, et al.* (2006)** Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell 5(6):972-80

Author(s)

Citation

Thammahong A, Caffrey-Card AK, Dhingra S, Obar JJ, Cramer RA

Thammahong A, et al. (2017) Aspergillus fumigatus Trehalose-Regulatory Subunit Homolog Moonlights To Mediate Cell Wall Homeostasis through Modulation of Chitin Synthase Activity. MBio 8(2)

Dhingra S, Cramer RA

Dhingra S and Cramer RA (2017) Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol 8:92

Ries LN, Beattie SR, Espeso EA, Cramer RA, Goldman GH

Ries LN, et al. (2016) Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics 203(1):335-52

Fuller KK, Cramer RA, Zegans ME, Dunlap JC, Loros JJ

Fuller KK, et al. (2016) Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates. MBio 7(5)

Dhingra S, Kowlaski CH, Thammahong A, Beattie SR, Bultman KM, Cramer RA

Dhingra S, et al. (2016) RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus. mSphere 1(2)

Lima Pde S, Chung D, Bailao AM, Cramer RA, Soares CM

Lima Pde S, et al. (2015) Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus. PLoS Negl Trop Dis 9(12):e0004282

Losada L, Barker BM, Pakala S, Pakala S, Joardar V, Zafar N, Mounaud S, Fedorova N, Nierman WC, Cramer RA

Losada L, et al. (2014) Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA. Mycopathologia 178(5-6):331-9

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H

Gsaller F, et al. (2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76

Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA

Chung D, et al. (2014) ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog 10(11):e1004487

Blosser SJ, Merriman B, Grahl N, Chung D, Cramer RA

Blosser SJ, et al. (2014) Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. Microbiology 160(Pt 11):2492-506

Shepardson KM, Ngo LY, Aimanianda V, Latge JP, Barker BM, Blosser SJ, Iwakura Y, Hohl TM, Cramer RA

Shepardson KM, et al. (2013) Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbes Infect 15(4):259-69

Willger SD, Cornish EJ, Chung D, Fleming BA, Lehmann MM, Puttikamonkul S, Cramer RA

Willger SD, et al. (2012) Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus. Eukaryot Cell 11(12):1557-67

Grahl N, Shepardson KM, Chung D, Cramer RA

Grahl N, et al. (2012) Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell 11(5):560-70

Grahl N, Dinamarco TM, Willger SD, Goldman GH, Cramer RA

Grahl N, et al. (2012) Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis. Mol Microbiol 84(2):383-99

Blosser SJ, Cramer RA

Blosser SJ and Cramer RA (2012) SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). Antimicrob Agents Chemother 56(1):248-57

Barker BM, Kroll K, Vodisch M, Mazurie A, Kniemeyer O, Cramer RA

Barker BM, et al. (2012) Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. BMC Genomics 13:62

Wezensky SJ, Cramer RA

Wezensky SJ and Cramer RA Jr (2011) Implications of hypoxic microenvironments during invasive aspergillosis. Med Mycol 49 Suppl 1:S120-4

Li H, Barker B, Grahl N, Puttikamonkul S, Bell JD, Craven KD, Cramer RA Jr

Li H, et al. (2011) The small GTPase RacA mediates intracellular reactive oxygen species production, polarized growth, and virulence in the human fungal pathogen Aspergillus fumigatus. Eukaryot Cell 10(2):174-86

Grahl N, Puttikamonkul S, Macdonald JM, Gamcsik MP, Ngo LY, Hohl TM, Cramer RA

Grahl N, et al. (2011) In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog 7(7):e1002145

Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latge JP, Woollett L, Newman SL, Cramer RA Jr, Rhodes JC, Askew DS

Feng X, et al. (2011) HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 7(10):e1002330

Cramer RA, Rivera A, Hohl TM

Cramer RA, et al. (2011) Immune responses against Aspergillus fumigatus: what have we learned? Curr Opin Infect Dis 24(4):315-22

Blatzer M, Barker BM, Willger SD, Beckmann N, Blosser SJ, Cornish EJ, Mazurie A, Grahl N, Haas H, Cramer RA

Blatzer M, et al. (2011) SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374

Willger SD, Grahl N, Cramer RA Jr

Willger SD, et al. (2009) Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol 47 Suppl 1:S72-9

Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA Jr, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ

Pinchai N, et al. (2009) Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell 8(4):511-9

Kim KH, Willger SD, Park SW, Puttikamonkul S, Grahl N, Cho Y, Mukhopadhyay B, Cramer RA Jr, Lawrence CB

Kim KH, et al. (2009) TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen. PLoS Pathog 5(11):e1000653

Willger SD, Puttikamonkul S, Kim KH, Burritt JB, Grahl N, Metzler LJ, Barbuch R, Bard M, Lawrence CB, Cramer RA Jr

Willger SD, et al. (2008) A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog 4(11):e1000200

Cramer RA Jr, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ

Cramer RA Jr, et al. (2008) Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell 7(7):1085-97

Steinbach WJ, Reedy JL, Cramer RA Jr, Perfect JR, Heitman J

Steinbach WJ, et al. (2007) Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol 5(6):418-30

Steinbach WJ, Cramer RA Jr, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR

Steinbach WJ, et al. (2007) Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother 51(8):2979-81

Perrin RM, Fedorova ND, Bok JW, Cramer RA, Wortman JR, Kim HS, Nierman WC, Keller NP

Perrin RM, et al. (2007) Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathog 3(4):e50

Steinbach WJ, Cramer RA Jr, Perfect BZ, Asfaw YG, Sauer TC, Najvar LK, Kirkpatrick WR, Patterson TF, Benjamin DK Jr, Heitman J, Perfect JR

Steinbach WJ, et al. (2006) Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5(7):1091-103

Cramer RA Jr, Stajich JE, Yamanaka Y, Dietrich FS, Steinbach WJ, Perfect JR

Cramer RA Jr, et al. (2006) Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. Gene 383:24-32

Cramer RA Jr, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ

Cramer RA Jr, et al. (2006) Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell 5(6):972-80

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To cite AspGD, please use the following reference: Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, Miyasato SR, Binkley J, Orvis J, Shah P, Wymore F, Sherlock G, Wortman JR (2014). The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res 42 (1); D705-10; see How to cite AspGD.