AspGD Curated Papers

Author(s)	Citation
Sheridan KJ, Lechner BE, Keeffe GO, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S	*Sheridan KJ, et al.* (2016)** Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Sci Rep 6:35306
Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Muller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ	*Gsaller F, et al.* (2016)** Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog 12(7):e1005775
Schafferer L, Beckmann N, Binder U, Brosch G, Haas H	*Schafferer L, et al.* (2015)** AmcA-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis. Front Microbiol 6:252
Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA	*Hortschansky P, et al.* (2015)** Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10):6058-70
Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM	*Bertuzzi M, et al.* (2015)** Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog 11(6):e1004943
Baldin C, Valiante V, Kruger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA	*Baldin C, et al.* (2015)** Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13):2230-43
Wiemann P, Lechner BE, Baccile JA, Velk TA, Yin WB, Bok JW, Pakala S, Losada L, Nierman WC, Schroeder FC, Haas H, Keller NP	*Wiemann P, et al.* (2014)** Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front Microbiol 5:530
Petrik M, Haas H, Laverman P, Schrettl M, Franssen GM, Blatzer M, Decristoforo C	*Petrik M, et al.* (2014)** 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine E for Aspergillus infection imaging: uptake specificity in various microorganisms. Mol Imaging Biol 16(1):102-8
Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H	*Gsaller F, et al.* (2014)** The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76
Franken AC, Lechner BE, Werner ER, Haas H, Lokman BC, Ram AF, van den Hondel CA, de Weert S, Punt PJ	*Franken AC, et al.* (2014)** Genome mining and functional genomics for siderophore production in Aspergillus niger. Brief Funct Genomics 13(6):482-92
Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA	*Chung D, et al.* (2014)** ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog 10(11):e1004487
Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM	*Bertuzzi M, et al.* (2014)** The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. PLoS Pathog 10(10):e1004413
Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D	*Steinchen W, et al.* (2013)** Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79(21):6670-6
Leal SM Jr, Roy S, Vareechon C, Carrion SD, Clark H, Lopez-Berges MS, Dipietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E	*Leal SM Jr, et al.* (2013)** Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog 9(7):e1003436
Grundlinger M, Yasmin S, Lechner BE, Geley S, Schrettl M, Hynes M, Haas H	*Grundlinger M, et al.* (2013)** Fungal siderophore biosynthesis is partially localized in peroxisomes. Mol Microbiol 88(5):862-75
Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H	*Grundlinger M, et al.* (2013)** Aspergillus fumigatus SidJ mediates intracellular siderophore hydrolysis. Appl Environ Microbiol 79(23):7534-6
Franken AC, Werner ER, Haas H, Lokman BC, Van Den Hondel CA, Ram AF, de Weert S, Punt PJ	*Franken AC, et al.* (2013)** The role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger. Appl Microbiol Biotechnol 97(22):9773-85
Beckmann N, Schafferer L, Schrettl M, Binder U, Talasz H, Lindner H, Haas H	*Beckmann N, et al.* (2013)** Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus. PLoS One 8(6):e67426
Amich J, Schafferer L, Haas H, Krappmann S	*Amich J, et al.* (2013)** Regulation of sulphur assimilation is essential for virulence and affects iron homeostasis of the human-pathogenic mould Aspergillus fumigatus. PLoS Pathog 9(8):e1003573
Yasmin S, Alcazar-Fuoli L, Grundlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H	*Yasmin S, et al.* (2012)** Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. Proc Natl Acad Sci U S A 109(8):E497-504
Petrik M, Franssen GM, Haas H, Laverman P, Hortnagl C, Schrettl M, Helbok A, Lass-Florl C, Decristoforo C	*Petrik M, et al.* (2012)** Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 39(7):1175-83
Petrik M, Haas H, Schrettl M, Helbok A, Blatzer M, Decristoforo C	*Petrik M, et al.* (2012)** In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging. Nucl Med Biol 39(3):361-9
Linde J, Hortschansky P, Fazius E, Brakhage AA, Guthke R, Haas H	*Linde J, et al.* (2012)** Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6:6
Haas H	Haas H (2012) Iron - A Key Nexus in the Virulence of Aspergillus fumigatus. Front Microbiol 3:28
Gsaller F, Eisendle M, Lechner BE, Schrettl M, Lindner H, Muller D, Geley S, Haas H	*Gsaller F, et al.* (2012)** The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus. Metallomics 4(12):1262-70
Vodisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O	*Vodisch M, et al.* (2011)** Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5):2508-24
Schrettl M, Haas H	Schrettl M and Haas H (2011) Iron homeostasis--Achilles' heel of Aspergillus fumigatus? Curr Opin Microbiol 14(4):400-5
Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA	*Jain R, et al.* (2011)** The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1):39-53
Blatzer M, Binder U, Haas H	*Blatzer M, et al.* (2011)** The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation. Fungal Genet Biol 48(11):1027-33
Blatzer M, Schrettl M, Sarg B, Lindner HH, Pfaller K, Haas H	*Blatzer M, et al.* (2011)** SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol 77(14):4959-66
Blatzer M, Barker BM, Willger SD, Beckmann N, Blosser SJ, Cornish EJ, Mazurie A, Grahl N, Haas H, Cramer RA	*Blatzer M, et al.* (2011)** SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374
Tribus M, Bauer I, Galehr J, Rieser G, Trojer P, Brosch G, Loidl P, Haas H, Graessle S	*Tribus M, et al.* (2010)** A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus. Mol Biol Cell 21(2):345-53
Thon M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA	*Thon M, et al.* (2010)** The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4):1098-113
Schrettl M, Ibrahim-Granet O, Droin S, Huerre M, Latge JP, Haas H	*Schrettl M, et al.* (2010)** The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages. Microbes Infect 12(12-13):1035-41
Schrettl M, Carberry S, Kavanagh K, Haas H, Jones GW, O'Brien J, Nolan A, Stephens J, Fenelon O, Doyle S	*Schrettl M, et al.* (2010)** Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin. PLoS Pathog 6(6):e1000952
Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jochl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H	*Schrettl M, et al.* (2010)** HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6(9):e1001124
Petrik M, Haas H, Dobrozemsky G, Lass-Florl C, Helbok A, Blatzer M, Dietrich H, Decristoforo C	*Petrik M, et al.* (2010)** 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51(4):639-45
Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP	*Chamilos G, et al.* (2010)** Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Med Mycol 48(3):506-10
Yasmin S, Abt B, Schrettl M, Moussa TA, Werner ER, Haas H	*Yasmin S, et al.* (2009)** The interplay between iron and zinc metabolism in Aspergillus fumigatus. Fungal Genet Biol 46(9):707-13
Wallner A, Blatzer M, Schrettl M, Sarg B, Lindner H, Haas H	*Wallner A, et al.* (2009)** Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus. Appl Environ Microbiol 75(12):4194-6
Jochl C, Loh E, Ploner A, Haas H, Huttenhofer A	*Jochl C, et al.* (2009)** Development-dependent scavenging of nucleic acids in the filamentous fungus Aspergillus fumigatus. RNA Biol 6(2):179-86
Seifert M, Nairz M, Schroll A, Schrettl M, Haas H, Weiss G	*Seifert M, et al.* (2008)** Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis. Immunobiology 213(9-10):767-78
Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H	*Schrettl M, et al.* (2008)** SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1):27-43
Purschwitz J, Muller S, Kastner C, Schoser M, Haas H, Espeso EA, Atoui A, Calvo AM, Fischer R	*Purschwitz J, et al.* (2008)** Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans. Curr Biol 18(4):255-9
McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E	*McDonagh A, et al.* (2008)** Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4(9):e1000154
Jochl C, Rederstorff M, Hertel J, Stadler PF, Hofacker IL, Schrettl M, Haas H, Huttenhofer A	*Jochl C, et al.* (2008)** Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis. Nucleic Acids Res 36(8):2677-89
Blum G, Perkhofer S, Haas H, Schrettl M, Wurzner R, Dierich MP, Lass-Florl C	*Blum G, et al.* (2008)** Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob Agents Chemother 52(4):1553-5
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN Jr, Haynes K, Haas H	*Schrettl M, et al.* (2007)** Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog 3(9):1195-207
Kragl C, Schrettl M, Abt B, Sarg B, Lindner HH, Haas H	*Kragl C, et al.* (2007)** EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus. Eukaryot Cell 6(8):1278-85
Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thon M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H	*Hortschansky P, et al.* (2007)** Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13):3157-68
Eisendle M, Schrettl M, Kragl C, Muller D, Illmer P, Haas H	*Eisendle M, et al.* (2006)** The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell 5(10):1596-603
Tribus M, Galehr J, Trojer P, Brosch G, Loidl P, Marx F, Haas H, Graessle S	*Tribus M, et al.* (2005)** HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress. Eukaryot Cell 4(10):1736-45
Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW	*Nierman WC, et al.* (2005)** Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438(7071):1151-6
Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN Jr, Haynes K, Haas H	*Schrettl M, et al.* (2004)** Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med 200(9):1213-9
Eisendle M, Oberegger H, Buttinger R, Illmer P, Haas H	*Eisendle M, et al.* (2004)** Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans. Eukaryot Cell 3(2):561-3
Trojer P, Brandtner EM, Brosch G, Loidl P, Galehr J, Linzmaier R, Haas H, Mair K, Tribus M, Graessle S	*Trojer P, et al.* (2003)** Histone deacetylases in fungi: novel members, new facts. Nucleic Acids Res 31(14):3971-81
Oberegger H, Eisendle M, Schrettl M, Graessle S, Haas H	*Oberegger H, et al.* (2003)** 4'-phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans. Curr Genet 44(4):211-5
Haas H, Schoeser M, Lesuisse E, Ernst JF, Parson W, Abt B, Winkelmann G, Oberegger H	*Haas H, et al.* (2003)** Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J 371(Pt 2):505-13
Haas H	Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62(4):316-30
Greene AV, Keller N, Haas H, Bell-Pedersen D	*Greene AV, et al.* (2003)** A circadian oscillator in Aspergillus spp. regulates daily development and gene expression. Eukaryot Cell 2(2):231-7
Eisendle M, Oberegger H, Zadra I, Haas H	*Eisendle M, et al.* (2003)** The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49(2):359-75
Oberegger H, Schoeser M, Zadra I, Schrettl M, Parson W, Haas H	*Oberegger H, et al.* (2002)** Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans. Appl Environ Microbiol 68(11):5769-72
Oberegger H, Zadra I, Schoeser M, Abt B, Parson W, Haas H	*Oberegger H, et al.* (2002)** Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Biochem Soc Trans 30(4):781-3
Oberegger H, Schoeser M, Zadra I, Abt B, Haas H	*Oberegger H, et al.* (2001)** SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans. Mol Microbiol 41(5):1077-89
Conlon H, Zadra I, Haas H, Arst HN Jr, Jones MG, Caddick MX	*Conlon H, et al.* (2001)** The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Mol Microbiol 40(2):361-75
Zadra I, Abt B, Parson W, Haas H	*Zadra I, et al.* (2000)** xylP promoter-based expression system and its use for antisense downregulation of the Penicillium chrysogenum nitrogen regulator NRE. Appl Environ Microbiol 66(11):4810-6
Oberegger H, Zadra I, Schoeser M, Haas H	*Oberegger H, et al.* (2000)** Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus. FEBS Lett 485(2-3):113-6
Graessle S, Dangl M, Haas H, Mair K, Trojer P, Brandtner EM, Walton JD, Loidl P, Brosch G	*Graessle S, et al.* (2000)** Characterization of two putative histone deacetylase genes from Aspergillus nidulans. Biochim Biophys Acta 1492(1):120-6
Haas H, Zadra I, Stoffler G, Angermayr K	*Haas H, et al.* (1999)** The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J Biol Chem 274(8):4613-9
Angermayr K, Parson W, Stoffler G, Haas H	*Angermayr K, et al.* (1999)** Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. Biochim Biophys Acta 1453(2):304-10
Haas H, Marx F, Graessle S, Stoffler G	*Haas H, et al.* (1996)** Sequence analysis and expression of the Penicillium chrysogenum nitrate reductase encoding gene (niaD). Biochim Biophys Acta 1309(1-2):81-4
Marx F, Haas H, Hofer S, Stoffler G, Redl B	*Marx F, et al.* (1995)** Sequence and structure of Penicillium chrysogenum phoG, homologous to an acid phosphatase-encoding gene of Aspergillus nidulans. Gene 160(1):137-8

Author(s)

Citation

Sheridan KJ, Lechner BE, Keeffe GO, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S

Sheridan KJ, et al. (2016) Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Sci Rep 6:35306

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Muller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ

Gsaller F, et al. (2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog 12(7):e1005775

Schafferer L, Beckmann N, Binder U, Brosch G, Haas H

Schafferer L, et al. (2015) AmcA-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis. Front Microbiol 6:252

Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA

Hortschansky P, et al. (2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10):6058-70

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM

Bertuzzi M, et al. (2015) Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog 11(6):e1004943

Baldin C, Valiante V, Kruger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA

Baldin C, et al. (2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13):2230-43

Wiemann P, Lechner BE, Baccile JA, Velk TA, Yin WB, Bok JW, Pakala S, Losada L, Nierman WC, Schroeder FC, Haas H, Keller NP

Wiemann P, et al. (2014) Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front Microbiol 5:530

Petrik M, Haas H, Laverman P, Schrettl M, Franssen GM, Blatzer M, Decristoforo C

Petrik M, et al. (2014) 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine E for Aspergillus infection imaging: uptake specificity in various microorganisms. Mol Imaging Biol 16(1):102-8

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H

Gsaller F, et al. (2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19):2261-76

Franken AC, Lechner BE, Werner ER, Haas H, Lokman BC, Ram AF, van den Hondel CA, de Weert S, Punt PJ

Franken AC, et al. (2014) Genome mining and functional genomics for siderophore production in Aspergillus niger. Brief Funct Genomics 13(6):482-92

Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA

Chung D, et al. (2014) ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog 10(11):e1004487

Bertuzzi M, et al. (2014) The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. PLoS Pathog 10(10):e1004413

Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D

Steinchen W, et al. (2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79(21):6670-6

Leal SM Jr, Roy S, Vareechon C, Carrion SD, Clark H, Lopez-Berges MS, Dipietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E

Leal SM Jr, et al. (2013) Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog 9(7):e1003436

Grundlinger M, Yasmin S, Lechner BE, Geley S, Schrettl M, Hynes M, Haas H

Grundlinger M, et al. (2013) Fungal siderophore biosynthesis is partially localized in peroxisomes. Mol Microbiol 88(5):862-75

Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H

Grundlinger M, et al. (2013) Aspergillus fumigatus SidJ mediates intracellular siderophore hydrolysis. Appl Environ Microbiol 79(23):7534-6

Franken AC, Werner ER, Haas H, Lokman BC, Van Den Hondel CA, Ram AF, de Weert S, Punt PJ

Franken AC, et al. (2013) The role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger. Appl Microbiol Biotechnol 97(22):9773-85

Beckmann N, Schafferer L, Schrettl M, Binder U, Talasz H, Lindner H, Haas H

Beckmann N, et al. (2013) Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus. PLoS One 8(6):e67426

Amich J, Schafferer L, Haas H, Krappmann S

Amich J, et al. (2013) Regulation of sulphur assimilation is essential for virulence and affects iron homeostasis of the human-pathogenic mould Aspergillus fumigatus. PLoS Pathog 9(8):e1003573

Yasmin S, Alcazar-Fuoli L, Grundlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H

Yasmin S, et al. (2012) Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. Proc Natl Acad Sci U S A 109(8):E497-504

Petrik M, Franssen GM, Haas H, Laverman P, Hortnagl C, Schrettl M, Helbok A, Lass-Florl C, Decristoforo C

Petrik M, et al. (2012) Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 39(7):1175-83

Petrik M, Haas H, Schrettl M, Helbok A, Blatzer M, Decristoforo C

Petrik M, et al. (2012) In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging. Nucl Med Biol 39(3):361-9

Linde J, Hortschansky P, Fazius E, Brakhage AA, Guthke R, Haas H

Linde J, et al. (2012) Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6:6

Haas H

Haas H (2012) Iron - A Key Nexus in the Virulence of Aspergillus fumigatus. Front Microbiol 3:28

Gsaller F, Eisendle M, Lechner BE, Schrettl M, Lindner H, Muller D, Geley S, Haas H

Gsaller F, et al. (2012) The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus. Metallomics 4(12):1262-70

Vodisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O

Vodisch M, et al. (2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5):2508-24

Schrettl M, Haas H

Schrettl M and Haas H (2011) Iron homeostasis--Achilles' heel of Aspergillus fumigatus? Curr Opin Microbiol 14(4):400-5

Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA

Jain R, et al. (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1):39-53

Blatzer M, Binder U, Haas H

Blatzer M, et al. (2011) The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation. Fungal Genet Biol 48(11):1027-33

Blatzer M, Schrettl M, Sarg B, Lindner HH, Pfaller K, Haas H

Blatzer M, et al. (2011) SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol 77(14):4959-66

Blatzer M, Barker BM, Willger SD, Beckmann N, Blosser SJ, Cornish EJ, Mazurie A, Grahl N, Haas H, Cramer RA

Blatzer M, et al. (2011) SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet 7(12):e1002374

Tribus M, Bauer I, Galehr J, Rieser G, Trojer P, Brosch G, Loidl P, Haas H, Graessle S

Tribus M, et al. (2010) A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus. Mol Biol Cell 21(2):345-53

Thon M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA

Thon M, et al. (2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4):1098-113

Schrettl M, Ibrahim-Granet O, Droin S, Huerre M, Latge JP, Haas H

Schrettl M, et al. (2010) The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages. Microbes Infect 12(12-13):1035-41

Schrettl M, Carberry S, Kavanagh K, Haas H, Jones GW, O'Brien J, Nolan A, Stephens J, Fenelon O, Doyle S

Schrettl M, et al. (2010) Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin. PLoS Pathog 6(6):e1000952

Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jochl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H

Schrettl M, et al. (2010) HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6(9):e1001124

Petrik M, Haas H, Dobrozemsky G, Lass-Florl C, Helbok A, Blatzer M, Dietrich H, Decristoforo C

Petrik M, et al. (2010) 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51(4):639-45

Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP

Chamilos G, et al. (2010) Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Med Mycol 48(3):506-10

Yasmin S, Abt B, Schrettl M, Moussa TA, Werner ER, Haas H

Yasmin S, et al. (2009) The interplay between iron and zinc metabolism in Aspergillus fumigatus. Fungal Genet Biol 46(9):707-13

Wallner A, Blatzer M, Schrettl M, Sarg B, Lindner H, Haas H

Wallner A, et al. (2009) Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus. Appl Environ Microbiol 75(12):4194-6

Jochl C, Loh E, Ploner A, Haas H, Huttenhofer A

Jochl C, et al. (2009) Development-dependent scavenging of nucleic acids in the filamentous fungus Aspergillus fumigatus. RNA Biol 6(2):179-86

Seifert M, Nairz M, Schroll A, Schrettl M, Haas H, Weiss G

Seifert M, et al. (2008) Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis. Immunobiology 213(9-10):767-78

Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H

Schrettl M, et al. (2008) SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1):27-43

Purschwitz J, Muller S, Kastner C, Schoser M, Haas H, Espeso EA, Atoui A, Calvo AM, Fischer R

Purschwitz J, et al. (2008) Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans. Curr Biol 18(4):255-9

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E

McDonagh A, et al. (2008) Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4(9):e1000154

Jochl C, Rederstorff M, Hertel J, Stadler PF, Hofacker IL, Schrettl M, Haas H, Huttenhofer A

Jochl C, et al. (2008) Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis. Nucleic Acids Res 36(8):2677-89

Blum G, Perkhofer S, Haas H, Schrettl M, Wurzner R, Dierich MP, Lass-Florl C

Blum G, et al. (2008) Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob Agents Chemother 52(4):1553-5

Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN Jr, Haynes K, Haas H

Schrettl M, et al. (2007) Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog 3(9):1195-207

Kragl C, Schrettl M, Abt B, Sarg B, Lindner HH, Haas H

Kragl C, et al. (2007) EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus. Eukaryot Cell 6(8):1278-85

Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thon M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H

Hortschansky P, et al. (2007) Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13):3157-68

Eisendle M, Schrettl M, Kragl C, Muller D, Illmer P, Haas H

Eisendle M, et al. (2006) The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell 5(10):1596-603

Tribus M, Galehr J, Trojer P, Brosch G, Loidl P, Marx F, Haas H, Graessle S

Tribus M, et al. (2005) HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress. Eukaryot Cell 4(10):1736-45

Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW

Nierman WC, et al. (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438(7071):1151-6

Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN Jr, Haynes K, Haas H

Schrettl M, et al. (2004) Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med 200(9):1213-9

Eisendle M, Oberegger H, Buttinger R, Illmer P, Haas H

Eisendle M, et al. (2004) Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans. Eukaryot Cell 3(2):561-3

Trojer P, Brandtner EM, Brosch G, Loidl P, Galehr J, Linzmaier R, Haas H, Mair K, Tribus M, Graessle S

Trojer P, et al. (2003) Histone deacetylases in fungi: novel members, new facts. Nucleic Acids Res 31(14):3971-81

Oberegger H, Eisendle M, Schrettl M, Graessle S, Haas H

Oberegger H, et al. (2003) 4'-phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans. Curr Genet 44(4):211-5

Haas H, Schoeser M, Lesuisse E, Ernst JF, Parson W, Abt B, Winkelmann G, Oberegger H

Haas H, et al. (2003) Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J 371(Pt 2):505-13

Haas H

Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62(4):316-30

Greene AV, Keller N, Haas H, Bell-Pedersen D

Greene AV, et al. (2003) A circadian oscillator in Aspergillus spp. regulates daily development and gene expression. Eukaryot Cell 2(2):231-7

Eisendle M, Oberegger H, Zadra I, Haas H

Eisendle M, et al. (2003) The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49(2):359-75

Oberegger H, Schoeser M, Zadra I, Schrettl M, Parson W, Haas H

Oberegger H, et al. (2002) Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans. Appl Environ Microbiol 68(11):5769-72

Oberegger H, Zadra I, Schoeser M, Abt B, Parson W, Haas H

Oberegger H, et al. (2002) Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Biochem Soc Trans 30(4):781-3

Oberegger H, Schoeser M, Zadra I, Abt B, Haas H

Oberegger H, et al. (2001) SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans. Mol Microbiol 41(5):1077-89

Conlon H, Zadra I, Haas H, Arst HN Jr, Jones MG, Caddick MX

Conlon H, et al. (2001) The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Mol Microbiol 40(2):361-75

Zadra I, Abt B, Parson W, Haas H

Zadra I, et al. (2000) xylP promoter-based expression system and its use for antisense downregulation of the Penicillium chrysogenum nitrogen regulator NRE. Appl Environ Microbiol 66(11):4810-6

Oberegger H, Zadra I, Schoeser M, Haas H

Oberegger H, et al. (2000) Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus. FEBS Lett 485(2-3):113-6

Graessle S, Dangl M, Haas H, Mair K, Trojer P, Brandtner EM, Walton JD, Loidl P, Brosch G

Graessle S, et al. (2000) Characterization of two putative histone deacetylase genes from Aspergillus nidulans. Biochim Biophys Acta 1492(1):120-6

Haas H, Zadra I, Stoffler G, Angermayr K

Haas H, et al. (1999) The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J Biol Chem 274(8):4613-9

Angermayr K, Parson W, Stoffler G, Haas H

Angermayr K, et al. (1999) Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. Biochim Biophys Acta 1453(2):304-10

Haas H, Marx F, Graessle S, Stoffler G

Haas H, et al. (1996) Sequence analysis and expression of the Penicillium chrysogenum nitrate reductase encoding gene (niaD). Biochim Biophys Acta 1309(1-2):81-4

Marx F, Haas H, Hofer S, Stoffler G, Redl B

Marx F, et al. (1995) Sequence and structure of Penicillium chrysogenum phoG, homologous to an acid phosphatase-encoding gene of Aspergillus nidulans. Gene 160(1):137-8

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