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Suelmann R, Fischer R (2000) Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans. Cell Motil Cytoskeleton 45(1):42-50
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Abstract:Mitochondria are essential organelles for the oxidative energy metabolism in eukaryotic cells. Determinants of mitochondrial morphology as well as the machinery underlying their subcellular distribution are not well understood. In this study we constructed an Aspergillus nidulans strain, in which mitochondria are stained with the green-fluorescent protein (GFP) to visualize them and study their behavior in vivo (http://www.uni-marburg. de/mpi/movies/mitochondria/mitochondria.html). Mitochondria form a complex membranous system in the cytoplasm consisting of interconnected tubular structures. Mitochondrial tubes separate frequently or produce small organelles that migrate some distance with velocities of up to 15 microm/min before they fuse again with the reticulum. Experiments using cytochalasin A as an anti-cytoskeletal drug revealed that a functional actin cytoskeleton is crucial for mitochondrial morphology and the dynamic behavior of the mitochondrial network. Movement of organelles along actin filaments requires actin-dependent motor proteins, such as myosin. We found that MyoA, a class I myosin motor of A. nidulans involved in vesicle migration, is not responsible for mitochondrial movement.
Status:PublishedType:Research Support, Non-U.S. Gov'tPubMed ID:10618165

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Topics
Topics not linked to GenesGenes linked to topics
myoA
(A. nidulans)
Aspergillus nidulans/Emericella nidulans
Mutants/Phenotypes
Sensitivity/response to drugs/other treatments
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