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Oiartzabal-Arano E, Garzia A, Gorostidi A, Ugalde U, Espeso EA, Etxebeste O (2015) Beyond asexual development: modifications in the gene expression profile caused by the absence of the Aspergillus nidulans transcription factor FlbB. Genetics 199(4):1127-42
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Abstract:In the model fungus Aspergillus nidulans, asexual development is induced from vegetative hyphae by a set of early regulators including the bZIP-type transcription factor FlbB. To determine the range of genes under the influence of the transcriptional activity of FlbB and to characterize their role in fungal development, we sequenced and compared the transcriptomes of a DeltaflbB mutant and its isogenic wild-type strain at different developmental stages. Results confirmed the activating role of FlbB on downstream regulators of conidiation as flbD and brlA. However, FlbB has additional functions beyond the induction of asexual development. Among the observed changes, absence of a functional FlbB caused the induction of the dba cluster and the synthesis of a secondary metabolite with bactericidal properties. In addition, a new transcriptional target of FlbB was unveiled, urdA, which codes for a putative TF that represses premature sexual development. Taken together, results indicate that the activators of asexual development simultaneously exert a role on other cellular functions, including an inhibitory effect on the sexual cycle, and reinforce the hypothesis that mutually exclusive metabolic and cellular patterns are associated with different morphogenetic programs.
Status:PublishedType:Journal ArticlePubMed ID:25701285

Topics addressed in this paper
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Topics
Genes linked to topics
flbB
(A. nidulans)
Aspergillus nidulans/Emericella nidulans
Genomic expression study
Mutants/Phenotypes
Regulatory Role
Strains/Constructs
Transcriptional Regulation
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